axl — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T73300	AXL-IN-13		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
	AXL-IN-13 is a potent and orally active AXL inhibitor with an IC50 value of 1.6 nM and a Kd value of 0.26 nM.AXL-IN-13 exhibits anticancer activity, reverses TGF-β1-induced epithelial-mesenchymal transition (EMT) and inh...		FLT , TAM Receptor , PDGFR , TGF-beta/Smad
T3S0027	Picropodophyllotoxin	AXL 1717,Picropodophyllin	IGF-1R
	Picropodophyllotoxin (AXL 1717) is a cyclolignan alkaloid found in the mayapple plant family (Podophyllum peltatum), and a small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF1R) with potential anti...		IGF-1R
T63293	Axl-IN-7
	Axl-IN-7 is a potent inhibitor of AXL. Axl-IN-7 can be used to study Axl-related diseases such as cancer (e.g., acute myeloid leukemia, breast cancer, melanoma, pancreatic cancer, and glial tumors), immune system disorde...
T63683	Axl-IN-11
	Axl-IN-11 is a potent inhibitor of AXL. Axl-IN-11 can be used to study proliferative diseases, allergic diseases, autoimmune diseases, inflammatory diseases, cancer, transplant rejection, viral infectious diseases or oth...
T63154	Axl-IN-10
	Axl-IN-10 is a potent inhibitor of AXL (IC50: 5 nM).Axl-IN-10 has good pharmacokinetic properties in animals and excellent transmembrane properties.Axl-IN-10 can be used to study proliferative, allergic, autoimmune, infl...
T79969	Axl-IN-16		TAM Receptor
	Axl-IN-16, a dual Axl/HIF inhibitor, promotes Flammulina velutipes fruiting body formation and suppresses hypoxia-inducible factor activity along with receptor tyrosine kinase expression [1].		TAM Receptor
T73310	AXL-IN-14		TAM Receptor
	AXL-IN-14 is a potent, orally active inhibitor of AXL with an IC50 of 0.8 nM that effectively suppresses Gas6/AXL-mediated cell migration and invasion, reduces the expression of p-AXL and p-AKT proteins, and demonstrates...		TAM Receptor
T63320	Axl-IN-6
	Axl-IN-6 is an orally active inhibitor of AXL. Axl-IN-6 demonstrated good tolerance and significant inhibition of tumor growth in the MV-4-11 subcutaneous xenograft tumor model.
T63901	Axl-IN-8
	Axl-IN-8 (NO.1) is a potent inhibitor of AXL (IC50<1 nM) and also inhibits c-MET (IC50: 1-10 nM). : 120.3 nM).
T62778	Axl-IN-9
	Axl-IN-9 is a potent inhibitor of AXL (IC50: 26 nM) with excellent transmembrane properties.Axl-IN-9 exhibits good pharmacokinetic properties in animals.Axl-IN-9 can be used to study proliferative, autoimmune, allergic, ...
T60259	Axl-IN-4
	Axl-IN-4 (Compound 24) is an inhibitor of AXL kinase with an IC 50 of 28.8 μM [1].
T63817	Axl-IN-5
	Axl-IN-5 (compound 1) is an AXL inhibitor (IC50: 283 nM) that exhibits anticancer activity.
T63888	Axl-IN-12
	Axl-IN-12 is a potent inhibitor of AXL. Axl-IN-12 can be used to study proliferative, allergic, autoimmune, inflammatory, cancer, transplant rejection, viral infectious diseases or other mammalian diseases.
T62962	Axl-IN-3
	Axl-IN-3 is a selective, potent and orally active inhibitor of AXL kinase (IC50: 41.5 nM) and has a low inhibitory effect on other kinases.
T79045	AXL-IN-15		TAM Receptor
	AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1 nanomolar (nM). It is applicable for cancer research [1].		TAM Receptor
T6943	Picropodophyllin	AXL1717,Picropodophyllin (PPP),Picropodophyllotoxin,PPP	Apoptosis , IGF-1R
	Picropodophyllin (Picropodophyllin (PPP)) (PPP) is a specific IGF-1R inhibitor (IC50: 1 nM). Picropodophyllin specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with...		Apoptosis , IGF-1R
T74353	PROTAC Axl Degrader 1
	PROTAC Axl Degrader 1 is a potent, selective degrader of PROTAC Axl, exhibiting an IC50 of 0.92 µM. It demonstrates in vitro anti-proliferative and anti-migratory activities and induces mehuosis [1].
T74354	PROTAC Axl Degrader 2
	PROTAC Axl Degrader 2, a potent and selective PROTAC Axl degrader, demonstrates an IC50 of 1.61 µM. It exhibits anti-proliferative and anti-migratory activities in vitro and induces mehuosis [1].
T72574	Axl/Mer/CSF1R-IN-1
	Axl/Mer-IN-1 is a compound that functions as an inhibitor for Axl/Mer receptor tyrosine kinase (Axl/Mer RTK) and CSF1R, exhibiting dissociation constants (Kds) of less than 0.1 μM.
T6982	SGI-7079		FLT , c-Met/HGFR , c-RET , TAM Receptor , Src
	SGI-7079 is a new selective Axl inhibitor. SGI-7079 can be a dose-dependent manner inhibited growth of tumors. It is also a potential therapeutic target for EGFR inhibitor resistance.		FLT , c-Met/HGFR , c-RET , TAM Receptor , Src