atm — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10395L	ATM-3507		Others
	ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are from 3.83-6.84 μM.		Others
T62684	ATM Inhibitor-5
	ATM Inhibitor-5 [formula (1)] is a potent inhibitor of the serine/threonine protein kinase ATM.
T2685	KU-55933	ATM Kinase Inhibitor	ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
	KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor.		ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy
T70113	ATM-1001
	ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets.
T10395	ATM-3507 trihydrochloride (1861449-70-8 free base)	ATM-3507 trihydrochloride	Others
	ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).		Others
T10396	ATM Inhibitor-1		ATM/ATR
	ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity. It shows weak activity against mTOR (IC50, 21 μM), DNAPK (IC50, 2.8 μM), PI3Kα (IC50, 3.8 μM), PI3Kβ (IC50,...		ATM/ATR
T63714	ATM-IN-1
	ATM-IN-1 is a potent inhibitor of ATM. ATM-IN-1 has shown research potential in cancer and neurological diseases.
T79306	ATM Inhibitor-9		ATM/ATR
	ATM Inhibitor-9 (Compd 7a) is a potent inhibitor of ATM kinase, exhibiting an IC50 value of 5 nM, and is utilized in cancer research [1].		ATM/ATR
T79305	ATM Inhibitor-8		ATM/ATR
	ATM Inhibitor-8 (Compound 10r) is a potent, selective, and orally active inhibitor of ATM, exhibiting anti-tumor activity [1], characterized by an IC50 value of 1.15 nM.		ATM/ATR
T63279	ATM Inhibitor-2
	ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).
T63317	ATM Inhibitor-4
	ATM Inhibitor -4 is a selective and potent ATM inhibitor (IC50: 0.32 nM) that strongly inhibits the activity of the PI3K kinase family and exhibits good metabolic stability. ATM Inhibitor -4 completely inhibits mTOR at 1...
T63171	ATM Inhibitor-3
	ATM Inhibitor-3 is a potent and selective inhibitor of ATM (IC50: 0.71 nM). ATM Inhibitor-3 inhibits the PI3K kinase family and exhibits good metabolic stability.
T72218	ATM-3507 trihydrochloride
	ATM-3507 trihydrochloride, a potent inhibitor of tropomyosin, demonstrates inhibition concentration (IC50) values ranging from 3.83 to 6.84 μM across various human melanoma cell lines.
T5175	Azd1390		ATM/ATR
	AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes.		ATM/ATR
T3338	Ceralasertib	AZD6738	ATM/ATR
	Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM.		ATM/ATR
T4443	AZ32		ATM/ATR
	AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell.		ATM/ATR
T1958	AZ20		ATM/ATR , mTOR
	AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR.		ATM/ATR , mTOR
T6770	AZD0156		Apoptosis , ATM/ATR
	AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing.		Apoptosis , ATM/ATR
T1821	CGK733	CGK 733	ATM/ATR
	CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR.		ATM/ATR
T3032	VE-821	ATR Inhibitor IV	ATM/ATR
	VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays).		ATM/ATR