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ATM-3507 trihydrochloride (1861449-70-8 free base)

Catalog No. T10395 CAS T10395

Synonyms: ATM-3507 trihydrochloride

ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).

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ATM-3507 trihydrochloride (1861449-70-8 free base) Chemical Structure

ATM-3507 trihydrochloride (1861449-70-8 free base), CAS T10395

Pack Size	Availability	Price/USD
5 mg	Inquiry	$ 122.00
10 mg	Inquiry	$ 206.00
50 mg	Inquiry	$ 619.00
100 mg	Inquiry	$ 1,058.00
200 mg	Inquiry	Inquiry
500 mg	Inquiry	Inquiry
1 mL * 10 mM (in DMSO)	Inquiry	$ 191.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).
Targets&IC50	Tropomyosin (human melanoma cell lines):3.83-6.84 μM
In vivo	The maximal tolerance dose (MTD) for TR100 and ATM-3507 is 60 and 150 mg/kg, respectively. The median survival of mice increased from 18 days for mice treated with ATM-3507 to more than 49 days for mice treated with the combination. It is also found that twice-weekly intravenous administration of ATM-3507 also shows combination efficacy. The impact of each treatment or the combination of body weight is minimal. Drug levels are measured following the intravenous administration of ATM-3507 at 30 mg/kg in Balb/c mice (n=3 per time point). The mean half-life of ATM-3507 is 5.01 hrs for the terminal elimination phase. The mean AUC0-t in the plasma is 14,548 ng/h/mL. The Cmax of ATM-3507 is 5,758 ng/mL and the t1/2 is 5.01 h. The observed plasma clearance and volume of distribution at steady state of ATM-3507 is 33.8 mL/min/kg and 7.23 L/kg, respectively.

Synonyms	ATM-3507 trihydrochloride
Molecular Weight	721.17
Formula	C37H49Cl3FN5O2
CAS No.	T10395

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 250 mg/mL (346.66 mM), Sonication is recommended.

References and Literature

1. Currier MA, et al. Identification of Cancer-Targeted Tropomyosin Inhibitors and Their Synergy with Microtubule Drugs.Mol Cancer Ther. 2017 Aug;16(8):1555-1565.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ATM-3507 trihydrochloride (1861449-70-8 free base) T10395 Others 1861449-70-8 free base 1861449-70-8 ATM-3507 Trihydrochloride ATM-3507 trihydrochloride ATM3507 ATM-3507 ATM 3507 trihydrochloride (1861449 70 8 free base) ATM 3507 Trihydrochloride ATM3507 Trihydrochloride ATM 3507 ATM3507 trihydrochloride (1861449708 free base) inhibitor inhibit

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