13
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8961 | GW280264X | Carbamic acid | MMP |
GW280264X (Carbamic acid) is an inhibitor of ADAM17 . | |||
T6009 | TAPI1 | TAPI 1,TAPI,TAPI-1 | MMP |
TAPI1 (TAPI) , an ADAM17/TACE inhibitor, inhibits shedding of cytokine receptors. | |||
T27603 | INCB3619 | INCB-3619,INCB 3619 | Immunology/Inflammation related |
INCB3619 is a selective and potent inhibitor of ADAM with antitumour effects, inhibiting ADAM10, ADAM17, MMP12 and MMP15. | |||
T27654 | JG26 | JG 26,JG-26 | MMP , Immunology/Inflammation related |
JG26 is a potent inhibitor of ADAM17, which can inhibit ADAM8, ADAM17, ADAM10 and MMP-12, with IC50 values of 12 nM, 1.9 nM, 150 nM and 9.4 nM, respectively, and can be used to study the immune system of the body. | |||
T7522 | GI254023X | GI 254023X | MMP , Immunology/Inflammation related |
GI254023X is a potent MMP9 and ADAM10 inhibitor (IC50s: 2.5 and 5.3 nM) with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). GI254023X can remarkably inhibit the proliferation and induce the apoptosis... | |||
T13410 | ZLDI-8 | Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related | |
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein. | |||
T4122 | TAPI-1 trifluoroacetate (163847-77-6(free base)) | MMP | |
TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors. | |||
T26105 | Ro 32-7315 | Ro-327315,Ro327315,Ro 32 7315 | |
Ro 32-7315 is a selective inhibitor of ADAM17. | |||
T27592 | IK-862 | IK 862 | |
IK-862 is a selective inhibitor of TACE (ADAM17). | |||
T63390 | (S,S)-TAPI-1 | ||
(S,S)-TAPI-1 is an isomer of TAPI-1. Among them, TAPI-1 is a metalloproteinase (MMP) inhibitor and a TACE (ADAM17) inhibitor that exhibits potent inhibition of a variety of cell surface protein shedding. | |||
T40901 | Aderbasib | INCB007839,INCB7839 | |
Aderbasib (INCB007839) is a highly potent and orally active hydroxamate-based inhibitor of ADAM10 and ADAM17, with low nanomolar affinity. This compound demonstrates strong antineoplastic activity and holds potential for... | |||
T28985 | TMI-1 | WAY-171318 | Apoptosis , MMP |
TMI-1 (WAY-171318), a novel orally active inhibitor of ADAM17 (TACE) and MMP, induces tumor apoptosis in a breast cancer. | |||
T77778 | KP-457 | TNF‐α‐converting enzyme | |
KP-457 (TNF-α-converting enzyme) is a selective inhibitor of ADAM17, with an IC50 value of 11.1 nM/L in cell-free assays. The compound can also cleave a variety of molecules, including GPIbα, GPV and TNF-α. |