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TAPI-1 trifluoroacetate (163847-77-6(free base))

Catalog No. T4122   CAS T4122

TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
TAPI-1 trifluoroacetate (163847-77-6(free base)) Chemical Structure
TAPI-1 trifluoroacetate (163847-77-6(free base)), CAS T4122
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2 mg Inquiry $ 267.00
5 mg Inquiry $ 592.00
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Purity: 98.06%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TAPI-1 is an ADAM17/TACE inhibitor, which blocks shedding of cytokine receptors.
In vitro TAPI-1 prevents unstimulated and PMA-induced release of the soluble forms of TNF-alpha, p60 TNFR, and IL-6R from the monocytic cell line, THP-1, and from human peripheral blood monocytes. TAPI also inhibits LPS-induced shedding of the p60 TNFR and TNF-alpha from monocytes. TAPI-1 inhibits TACE-dependent constitutive release of co-transfected APP(695). TAPI-1 attenuates Ang II-induced EGFR transactivation and cell proliferation in human HSC line LI90. TAPI-1 with the EGFR inhibitor AG1478 exhibits deactivated AREG/EGFR/ERK signaling pathway and reduces pro-inflammatory cytokines release in pSS salivary gland-derived epithelial cells.
Molecular Weight 613.62
Formula C28H38F3N5O7
CAS No. T4122

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 10 mM

TargetMolReferences and Literature

1. Müllberg J, et al. J Immunol. 1995, 155(11), 5198-5205 2. Slack BE, et al. Biochem J. 2001, 357(Pt 3), 787-794. 3. Oikawa H, et al. Life Sci. 2014, 97(2), 137-144.

Related compound libraries

This product is contained In the following compound libraries:
Fluorochemical Library Nonsteroidal Anti-Inflammatory Compound Library NO PAINS Compound Library

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Keywords

TAPI-1 trifluoroacetate (163847-77-6(free base)) T4122 Proteases/Proteasome MMP TAPI1 trifluoroacetate (171235715(free base)) TAPI 1 trifluoroacetate (171235 71 5(free base)) inhibitor inhibit

 

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