aat — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T26497	AAT-008	AAT008
	AAT-008 is a PGE2 receptor EP4 antagonist.
TQ0292	Grapiprant	AAT-007,RQ-00000007,CJ-023423	Prostaglandin Receptor
	Grapiprant (AAT-007) is a selective EP4 receptor antagonist. Grapiprant displaces [3H]-PGE2 (1 nM) binding to dog recombinant EP4 receptor (IC50: 35 nM, Ki: 24 nM).		Prostaglandin Receptor
T9347	EAAT2 activator 1	3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine	transporter
	EAAT2 activator 1 (3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine) is a thiopyridazine derivative that has been found to increase EAAT2 protein levels in astrocytes.		transporter
T83297	5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT
	5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT is a fluorescein (FAM)-labeled oligonucleotide, denoted by the sequence provided.
T83298	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT
	5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT is a double-stranded ribonucleoside that is modified with the fluorescent molecule 5'6-FAM, a combination of 5-FAM and 6-FAM. The excitation/emission wavelengths of 5-F...
T39397	S-MGB-234
	S-MGB-234 is a minor groove binder utilized for the treatment of Animal African Trypanosomiasis (AAT). It exhibits exceptional in vitro efficacy against the primary causative agents of AAT, namely Trypanosoma congolense ...
T60768	SN05
	SN05 is a potent inhibitor of amino acid transport (AAT) that can be used in anticancer research. The Ki values of SN05 for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT2, EAAC1 and EAAT5 is 2.77 μM, 0.73 μM, 0.87 μM,...
T60642	SN40
	SN40 is a potent amino acid transport (AAT) inhibitor that can be used in anticancer research. SN40 has Kis of 7.29 μM, 2.42 μM, 2.94 μM, 5.55 μM, 24.43 μM and 5.55 μM for human ASCT1, rat ASCT2, human ASCT2, EAAT1, EAAT...
T73993	Fazirsiran
	Fazirsiran (ARO-AAT), a second-generation RNAi agent, comprises a cholesterol-conjugated RNAi trigger (chol-RNAi) that selectively degrades AAT mRNA via RNAi, and a melittin-derived peptide conjugated to N-acetylgalactos...

Compounds

AAT-008

T26497

Synonym: AAT-007,RQ-00000007,CJ-023423

Target: Prostaglandin Receptor

EAAT2 activator 1

T9347

Synonym: 3-[(2-Chloro-6-fluorobenzyl)thio]-6-pyridin-2-ylpyridazine

Target: transporter

5'6-FAM-UUCUCCGAACGUGUCACGUTT, ACGUGACACGUUCGGAGAATT

T83297

Synonym:

Target:

5'6-FAM-GGUGAAAGACGAUGGACAATT,UUGUCCAUCGUCUUUCACCTT

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-00915	Serpin A1 Protein, Human, Recombinant (His)	Human	HEK293
	SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit...
TMPJ-00505	Serpin A1 Protein, Human, Recombinant (aa 25-418, His)	Human	Human Cells
	Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent,...
TMPK-00305	TGFBR1 Protein, Human, Recombinant (mFc & Avi)	Human	HEK293
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPY-05157	TGFBR2 Protein, Human, Recombinant (His)	Human	Baculovirus-Insect Cells
	TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodoma...
TMPJ-00452	Serpin A1a Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Serpin A1a is also known as alpha-1-antitrypsin, is a member of the serpin superfamily of serine proteinase inhibitors that are involved in the regulation of a number of proteolytic processes. Its primary target is elast...
TMPK-01217	MFAP5 Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-assoc...
TMPK-00957	MFAP5 Protein, Human, Recombinant (hFc)	Human	HEK293
	Human basal-like breast cancer (BLBC) is an aggressive malignancy with poor prognosis. Since most current treatments are ineffective, there is an urgent need to identify therapeutic targets for BLBC. Microfibrillar-assoc...
TMPY-03052	MFAP5 Protein, Human, Recombinant (His)	Human	HEK293
	MFAP5 (Microfibril Associated Protein 5, also known as MAGP2) is a Protein Coding gene. MFAP5 is a component of the elastin-associated microfibrils. It belongs to the MFAP family. As a 25-kD microfibril-associated glycop...
TMPK-00329	TGFBR2 Protein, Human, Recombinant (mFc & Avi), Biotinylated	Human	HEK293
	The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called sign...
TMPK-00328	TGFBR2 Protein, Human, Recombinant (mFc & Avi)	Human	HEK293
	The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called sign...
TMPY-05810	TGFBR2 Protein, Human, Recombinant (His & hFc), Biotinylated	Human	HEK293
	TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodoma...
TMPK-00306	TGFBR1 Protein, Human, Recombinant (mFc & Avi), Biotinylated	Human	HEK293
	transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the sup...
TMPY-04366	ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)	Human	Baculovirus-Insect Cells
	Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPY-05771	ALK-5 Protein, Human, Recombinant (hFc)	Human	HEK293
	Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPY-05508	TGFBR2 Protein, Human, Recombinant (hFc)	Human	HEK293
	TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised of a C-terminal protein kinase domain and an N-terminal ectodomain. The ectodoma...
TMPY-01358	ALK-5 Protein, Human, Recombinant (His & hFc)	Human	HEK293
	Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPJ-01178	TGFBR1 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	TGF-beta RI, also called ALK-5, is an approximately 55 kDa type I transmembrane serine/threonine receptor kinase. In the presence of TGF-beta, TGF-beta RI forms a complex with, and is phosphorylated by, TGF-beta RII. Pho...
TMPY-00442	Serpin A1 Protein, Rat, Recombinant (His)	Rat	HEK293
	SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit...