Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Fazirsiran (ARO-AAT), a second-generation RNAi agent, comprises a cholesterol-conjugated RNAi trigger (chol-RNAi) that selectively degrades AAT mRNA via RNAi, and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) as the excipient EX1 to enhance endosomal escape of chol-RNAi in hepatocytes [1].
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Description | Fazirsiran (ARO-AAT), a second-generation RNAi agent, comprises a cholesterol-conjugated RNAi trigger (chol-RNAi) that selectively degrades AAT mRNA via RNAi, and a melittin-derived peptide conjugated to N-acetylgalactosamine (NAG) as the excipient EX1 to enhance endosomal escape of chol-RNAi in hepatocytes [1]. |
Molecular Weight | 15587.6 |
CAS No. | 2175009-08-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Fazirsiran 2175009-08-0 inhibitor inhibit