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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T9842 | 5-HT2B antagonist-1 | ||
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC 50 of 33.4 nM. It can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascu... | |||
T8357 | SB-200646 | 5-HT Receptor | |
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor | |||
T9146 | Ms48107 | Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- | Others |
MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch... | |||
T6973 | RS-127445 | MT500 | 5-HT Receptor |
RS-127445 (MT500) is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors. | |||
T7519 | RS-127445 hydrochloride | RS 127445,MT 500 | 5-HT Receptor |
RS-127445 hydrochloride (MT 500) is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5). | |||
T10871 | CP-809101 hydrochloride | 5-HT Receptor | |
CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors). | |||
T22947 | LY266097 hydrochloride | LY 266097 hydrochloride | 5-HT Receptor |
LY266097 hydrochloride (LY 266097 hydrochloride) is an antagonist of 5-HT2 with pKis of 7.7, 9.8, and 7.6 for human 5-HT2A, 5-HT2B, and 5-HT2C and can be used in studies about depression. | |||
T7350 | Nelotanserin | APD125 | 5-HT Receptor |
Nelotanserin (APD125) is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agonistt(IC50 : 791 nM). | |||
T16856 | SB228357 | 5-HT Receptor | |
SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively. | |||
T12489L | Pimethixene maleate | Pimetixene maleate | Dopamine Receptor , 5-HT Receptor , AChR , Histamine Receptor |
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we... | |||
T7498 | Eltoprazine hydrochloride | DU 28853 hydrochloride | 5-HT Receptor |
Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively). | |||
T16401 | Org-12962 | 5-HT Receptor | |
Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptor... | |||
T6423 | BRL-15572 dihydrochloride | BRL 15573 dihydrochloride | 5-HT Receptor |
BRL-15572 dihydrochloride (BRL 15573 dihydrochloride) is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B recepto... | |||
T23168 | PNU 22394 hydrochloride | 5-HT Receptor | |
PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist | |||
T23396 | ST1936 | ST 1936 oxalate | 5-HT Receptor |
ST1936 (ST 1936 oxalate) is a selective and potent 5-HT6 receptor agonist that inhibits human 5-HT6, 5-HT7, and 5-HT2B receptors, and stimulates cAMP, Ca2+, ERK1/2, and Fyn kinases through the complete activation of the ... | |||
T23312 | SB 204741 | 5-HT Receptor | |
SB 204741 is a 5-HT2B receptor antagonist. | |||
T22948 | LY 272015 hydrochloride | Others | |
LY 272015 hydrochloride is a 5-HT2B receptor antagonist. | |||
T16378 | Ogerin | Others , 5-HT Receptor , Adenosine Receptor | |
Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptor and weak an... | |||
T14782 | Brilaroxazine | RP5063 | Dopamine Receptor , 5-HT Receptor |
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... | |||
T12489 | Pimethixene | Calmixen,Pimetixene | Dopamine Receptor , 5-HT Receptor , AChR , Histamine Receptor |
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ... |