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Search Results for " 5-ht2b "

20

Compounds

Cat No. Product Name Synonyms Targets
T9842 5-HT2B antagonist-1
5-HT2B antagonist-1 is an orally active 5-HT2B receptor antagonist with an IC 50 of 33.4 nM. It can be used in studies of diseases characterized by 5-HT2B receptor signaling, such as hepatocellular carcinoma, cardiovascu...
T8357 SB-200646 5-HT Receptor
SB-200646 is a selective and potent antagonist of 5-HT2B/5-HT2C receptor
T9146 Ms48107 Benzenemethanol, 2-[4-amino-6-[[(4-phenoxyphenyl)methyl]amino]-1,3,5-triazin-2-yl]-3-fluoro- Others
MS48107 is a potent, selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68), demonstrating specificity for GPR68 over closely related proton GPCRs, neurotransmitter transporters, and hERG ion ch...
T6973 RS-127445 MT500 5-HT Receptor
RS-127445 (MT500) is a selective 5-HT2B receptor antagonist with pKi of 9.5 and pIC50 of 10.4, exhibits >1000-fold selectivity against other 5-HT receptors.
T7519 RS-127445 hydrochloride RS 127445,MT 500 5-HT Receptor
RS-127445 hydrochloride (MT 500) is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).
T10871 CP-809101 hydrochloride 5-HT Receptor
CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
T22947 LY266097 hydrochloride LY 266097 hydrochloride 5-HT Receptor
LY266097 hydrochloride (LY 266097 hydrochloride) is an antagonist of 5-HT2 with pKis of 7.7, 9.8, and 7.6 for human 5-HT2A, 5-HT2B, and 5-HT2C and can be used in studies about depression.
T7350 Nelotanserin APD125 5-HT Receptor
Nelotanserin (APD125) is a potent 5-HT2A inverse agonist(IC50 : 1.7 nM), a moderately potent 5-HT2C partial inverse agonist t(IC50 :79 nM )and a weak 5-HT2B inverse agonistt(IC50 : 791 nM).
T16856 SB228357 5-HT Receptor
SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively.
T12489L Pimethixene maleate Pimetixene maleate Dopamine Receptor , 5-HT Receptor , AChR , Histamine Receptor
Pimethixene maleate (Pimetixene maleate) is a potent 5-HT2B receptor antagonist with sedative and antitussive activity.Pimethixene maleate inhibits 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as we...
T7498 Eltoprazine hydrochloride DU 28853 hydrochloride 5-HT Receptor
Eltoprazine hydrochloride (DU 28853 hydrochloride) is a partial agonist at serotonin 5-HT1A, 5-HT1B, and 5-HT2B receptors (Ki value of 40, 52, and 81 nM, respectively).
T16401 Org-12962 5-HT Receptor
Org-12962 is an effective and selective 5-HT2C receptor agonist pEC50: 7.01). Org-12962 shows antiaversive effects in a rat model of panic-like anxiety. Org-12962 also shows high effacy for the 5-HT2A and 5-HT2B receptor...
T6423 BRL-15572 dihydrochloride BRL 15573 dihydrochloride 5-HT Receptor
BRL-15572 dihydrochloride (BRL 15573 dihydrochloride) is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B recepto...
T23168 PNU 22394 hydrochloride 5-HT Receptor
PNU 22394 hydrochloride is a 5-HT2C agonist and partial 5-HT2A/5-HT2B agonist
T23396 ST1936 ST 1936 oxalate 5-HT Receptor
ST1936 (ST 1936 oxalate) is a selective and potent 5-HT6 receptor agonist that inhibits human 5-HT6, 5-HT7, and 5-HT2B receptors, and stimulates cAMP, Ca2+, ERK1/2, and Fyn kinases through the complete activation of the ...
T23312 SB 204741 5-HT Receptor
SB 204741 is a 5-HT2B receptor antagonist.
T22948 LY 272015 hydrochloride Others
LY 272015 hydrochloride is a 5-HT2B receptor antagonist.
T16378 Ogerin Others , 5-HT Receptor , Adenosine Receptor
Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83). Ogerin blocks recall in fear conditioning in mice. Ogerin displays inverse agonist and antagonist activity (Ki, 220 nM) at A2A receptor and weak an...
T14782 Brilaroxazine RP5063 Dopamine Receptor , 5-HT Receptor
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-...
T12489 Pimethixene Calmixen,Pimetixene Dopamine Receptor , 5-HT Receptor , AChR , Histamine Receptor
Pimethixene (Calmixen) is a highly potent 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors antagonist(pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 ...
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