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SB228357

Name: SB228357
Brand: TargetMol
SKU: T16856
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16856Cas No. 181629-93-6

SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively.

SB228357

🥰Excellent

Purity: 99.82%

Catalog No. T16856Cas No. 181629-93-6

SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively.

Pack Size	Price	Availability
1 mg	$41	In Stock
5 mg	$107	In Stock
10 mg	$178	In Stock
25 mg	$295	In Stock
50 mg	$392	In Stock
100 mg	$536	In Stock
1 mL x 10 mM (in DMSO)	$101	In Stock

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Batch Information

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Purity:99.82%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	SB228357 is a potent and selective antagonist of the 5-HT receptor with pKis of 6.9, 8.0, and 9.0 for 5-HT2A, 5-HT2B, and 5-HT2C, respectively.
Targets&IC50	5-HT2C receptor:9 （pki）, 5-HT2A receptor:6.9 （pki）, 5-HT2B receptor:8 （pki）
In vivo	In male Sprague Dawley rats, oral administration of SB228357 (0-10 mg/kg) reverses Haloperidol-induced catalepsy obviously[2].

Chemical Properties

Molecular Weight	431.38
Formula	C₂₂H₁₇F₄N₃O₂
Cas No.	181629-93-6
Smiles	COc1cc2CCN(C(=O)Nc3cc(F)cc(c3)-c3cccnc3)c2cc1C(F)(F)F
Relative Density.	1.398 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 38.9 mg/mL (90.18 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3181 mL	11.5907 mL	23.1814 mL	115.9071 mL
5 mM	0.4636 mL	2.3181 mL	4.6363 mL	23.1814 mL
10 mM	0.2318 mL	1.1591 mL	2.3181 mL	11.5907 mL
20 mM	0.1159 mL	0.5795 mL	1.1591 mL	5.7954 mL
50 mM	0.0464 mL	0.2318 mL	0.4636 mL	2.3181 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc