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CP-809101 hydrochloride

Catalog No. T10871 CAS 1215721-40-6

CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).

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CP-809101 hydrochloride Chemical Structure

CP-809101 hydrochloride, CAS 1215721-40-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
2 mg	In stock	$ 46.00
5 mg	In stock	$ 75.00
10 mg	In stock	$ 117.00
25 mg	In stock	$ 258.00
50 mg	In stock	$ 479.00
100 mg	In stock	$ 686.00

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Purity: 99.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CP-809101 hydrochloride is a potent and selective 5-HT2C receptor agonist (pEC50: 9.96/7.19/6.81 for human 5-HT2C/5-HT2B/5-HT2A receptors).
Targets&IC50	5-HT2B:7.19(pEC50 for human), 5-HT2C:9.96(pEC50 for human), 5-HT2A:6.81(pEC50 for human)
In vitro	CP-809101 is a potent, functionally selective 5-HT2C agonist that displays approximately 100% efficacy in vitro[4].
In vivo	Similar to currently available antipsychotic drugs, CP-809101 dose-dependently inhibited conditioned avoidance responding (CAR, ED50 = 4.8 mg/kg, sc). CP-809101 antagonized both PCP- and d-amphetamine-induced hyperactivity with ED50 values of 2.4 and 2.9 mg/kg (sc), respectively, and also reversed an apomorphine induced-deficit in prepulse inhibition. At doses up to 56 mg/kg, CP-809101 did not produce catalepsy. CP-809101 was inactive in two animal models of antidepressant-like activity, the forced swim test, and learned helplessness[4].

Molecular Weight	341.24
Formula	C15H18Cl2N4O
CAS No.	1215721-40-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 20 mg/mL (58.61 mM), Sonification is recommended.

References and Literature

1. Higgins GA, Silenieks LB, Lau W, et al. Evaluation of chemically diverse 5-HT2C receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. 2. Strong PV, Christianson JP, Loughridge AB, et al. 5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior. Neuroscience. 2011 Dec 1;197:132-44. doi: 10.1016/j.neuroscience.2011.09.041. Epub 2011 Sep 24. 3. Fletcher PJ, Tampakeras M, Sinyard J et al. Characterizing the effects of 5-HT(2C) receptor ligands on motor activity and feeding behaviour in 5-HT(2C) receptor knockout mice. Neuropharmacology. 2009 Sep;57(3):259-67. doi: 10.1016/j.neuropharm.2009.05.011. 4. Siuciak JA, Chapin DS, McCarthy SA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Parkinson's Disease Compound Library Angiogenesis related Compound Library Serotonin Receptor-Targeted Compound Library Neurotransmitter Receptor Compound Library Antidepressant Compound Library Anti-Cancer Compound Library Neuronal Signaling Compound Library Bioactive Compound Library

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Keywords

CP-809101 hydrochloride 1215721-40-6 GPCR/G Protein Neuroscience 5-HT Receptor CP809101 Hydrochloride CP 809101 hydrochloride hyperactivity nicotine dependence Inhibitor nicotine antipsychotic inhibit CP-809101 Serotonin Receptor CP809101 conditioned avoidance responding CP 809101 CP-809101 Hydrochloride CP 809101 Hydrochloride CP809101 hydrochloride 5-hydroxytryptamine Receptor inhibitor

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