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Search Results for " 4i "

12

Compounds

Cat No. Product Name Synonyms Targets
T8438 4i CHEMBL1269981,5-HT3 antagonist-4i 5-HT Receptor
4i (CHEMBL1269981) is a 5-HT3 receptor antagonist,It modulates the serotonergic system.
T2437 O4I2 O-4I2,O4I2 OCT
O4I2 is an effective Oct3/4 inducer in various human cell lines including human fibroblasts.
T2439 O4I1 OCT
O4I1 is an effective Oct3/4 inducer.
T74186 PROTAC-O4I2 Apoptosis , PROTACs
PROTAC-O4I2, a PROTAC ligand targeting splicing factor 3B1 (SF3B1), induced FLAG-SF3B1 degradation in K562 cells with an IC50 value of 0.244 μM. PROTAC-O4I2 induced apoptosis in K562 WT cells.
T39335 Anti-virus agent 1 Anti-virus agent 1,Remdesivir isopropyl ester analog
Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734, exhibits potent antiviral efficacy. It is primarily utilized in the study of coronavirus and Ebola virus (EBOV).
T61255 SDH-IN-1
SDH-IN-1 (compound 4i) is a potent succinate dehydrogenase (SDH) inhibitor, exhibiting an IC 50 value of 4.53 μM. This compound displays strong antifungal properties, particularly against S. sclerotiorum, with an EC 50 v...
T78862 EGFR-IN-86 EGFR
EGFR-IN-86 (compound 4i), an EGFR inhibitor (IC50: 1.5 nM), demonstrates potent activity against glioblastoma by inducing apoptosis and causing G2/M phase cell cycle arrest in U87 cells [1].
T61426 NOS-IN-2
NOS-IN-2 (Compound 4i), an imidamide-derived NOS inhibitor, exhibits high potency and selectivity, specifically inhibiting iNOS with an IC50 of 20 μM while sparing eNOS. Demonstrating minimal toxicity, it is suitable for...
T79694 EGFR-IN-88 EGFR
EGFR-IN-88 (Compound 4i), an EGFR inhibitor with an IC50 of 87 nM, exhibits cytotoxic effects on A549 cells at an IC50 of 3.902 μM and can induce cell apoptosis [1].
T79686 FGFR1 inhibitor-10 FGFR
FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation. This compound demonstrates anti-angiogenic and anti-invasion properties, as well as a significant anti-tumor effect [1]...
T60714 Gp120-IN-2
gp120-IN-2 (compound 4i) exhibits anti-HIV-1 activity which is a potent inhibitor of HIV-1 gp120 with an IC 50 of 7.5 μM and CC 50 of 112.93 μM. gp120-IN-2 dose-dependently shows cytotoxicity in SUP-T1 cells [1].
T79714 HDAC3-IN-2 HDAC
HDAC3-IN-2 (compound 4i), a pyrazinyl hydrazide-based HDAC3 inhibitor with an IC50 of 14 nM, effectively targets triple-negative breast cancer cells. Demonstrating cytotoxic activity, HDAC3-IN-2 exhibits an IC50 of 0.55 ...
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