G protein-coupled receptors (GPCRs) form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. GPCRs are found only in eukaryotes, including yeast, and choanoflagellates. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters.
GPCRs are involved in many diseases such as mental, metabolic including endocrinological disorders, immunological including viral infections, cardiovascular, inflammatory, senses disorders, and cancer. Therefore, GPCRs are an important drug target and approximately 34% of all Food and Drug Administration (FDA) approved drugs target 108 members of this family.
Cat No. | product name / Synonyms | Species | Expression System |
---|---|---|---|
TMPJ-00354 | FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)
FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)
|
Mouse | HEK293 Cells |
Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signaling by serving as a co-receptor w... | |||
TMPJ-01037 | CXCR4 Protein, Human, Recombinant (hFc)
CXCR4 Protein, Human, Recombinant (hFc)
|
Human | HEK293 Cells |
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with ... | |||
TMPJ-01331 | Frizzled-8 Protein, Human, Recombinant (His & Avi), Biotinylated
Frizzled-8 Protein, Human, Recombinant (His & Avi), Biotinylated
|
Human | HEK293 Cells |
Frizzled-8 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 2... | |||
TMPJ-01332 | Frizzled-8 Protein, Human, Recombinant (His)
Frizzled-8 Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
Frizzled-8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-32 KDa and the accessi... | |||
TMPK-00528 | GPRC5D Protein-VLP, Cynomolgus, Recombinant
GPRC5D Protein-VLP, Cynomolgus, Recombinant
|
Cynomolgus | HEK293 Cells |
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orph... | |||
TMPK-00743 | LGR-5 Protein, Human, Recombinant (hFc)
LGR-5 Protein, Human, Recombinant (hFc)
|
Human | HEK293 Cells |
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a thera... | |||
TMPK-00861 | A2AR Protein-VLP, Human, Recombinant
A2AR Protein-VLP, Human, Recombinant
|
Human | HEK293 Cells |
Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound receptors for adenosine have been identified and cDNAs for A1, A2a, A2b, and A3... | |||
TMPK-00879 | CCR2b Protein-VLP, Human, Recombinant
CCR2b Protein-VLP, Human, Recombinant
|
Human | HEK293 Cells |
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant... | |||
TMPK-00896 | CCR8 Protein, Human, Recombinant (hFc)
CCR8 Protein, Human, Recombinant (hFc)
|
Human | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al... | |||
TMPK-00897 | CCR8 Protein, Human, Recombinant (mFc)
CCR8 Protein, Human, Recombinant (mFc)
|
Human | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al... | |||
TMPK-01193 | GPRC5D Protein-VLP, Mouse, Recombinant
GPRC5D Protein-VLP, Mouse, Recombinant
|
Mouse | HEK293 Cells |
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orph... | |||
TMPK-01316 | CCR8 Protein, Cynomolgus, Recombinant (mFc)
CCR8 Protein, Cynomolgus, Recombinant (mFc)
|
Cynomolgus | HEK293 Cells |
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al... | |||
TMPY-00085 | Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc)
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc)
|
Human | HEK293 Cells |
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.1 kDa a... | |||
TMPY-00181 | Endothelin B Receptor Protein, Human, Recombinant (His)
Endothelin B Receptor Protein, Human, Recombinant (His)
|
Human | HEK293 Cells |
Endothelin B Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 9.5 kDa and the ac... | |||
TMPY-00197 | Frizzled 4 Protein, Human, Recombinant (hFc)
Frizzled 4 Protein, Human, Recombinant (hFc)
|
Human | HEK293 Cells |
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ... | |||
TMPY-00313 | Frizzled 4 Protein, Rat, Recombinant (His)
Frizzled 4 Protein, Rat, Recombinant (His)
|
Rat | HEK293 Cells |
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ... | |||
TMPY-00317 | Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)
|
Human | HEK293 Cells |
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.9 kDa ... | |||
TMPY-00577 | Frizzled 6 Protein, Human, Recombinant (mFc)
Frizzled 6 Protein, Human, Recombinant (mFc)
|
Human | HEK293 Cells |
Frizzled 6 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 42 kDa and the accession numb... | |||
TMPY-01165 | FZD1/Frizzled 1 Protein, Mouse, Recombinant (His)
FZD1/Frizzled 1 Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 Cells |
Frizzled-1, also known as FZD1, belongs to theG-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal ... | |||
TMPY-01231 | Renin Protein, Mouse, Recombinant (His)
Renin Protein, Mouse, Recombinant (His)
|
Mouse | HEK293 Cells |
Renin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.2 kDa and the accession number ... |