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G Protein-Coupled Receptors, GPCRs

G protein-coupled receptors (GPCRs) form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. GPCRs are found only in eukaryotes, including yeast, and choanoflagellates. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters.

GPCRs are involved in many diseases such as mental, metabolic including endocrinological disorders, immunological including viral infections, cardiovascular, inflammatory, senses disorders, and cancer. Therefore, GPCRs are an important drug target and approximately 34% of all Food and Drug Administration (FDA) approved drugs target 108 members of this family.

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Species
Cynomolgus (2)
Human (41)
Mouse (10)
Rat (2)
Expression System
Baculovirus Insect Cells (1)
CHO Cells (1)
E. coli (2)
HEK293 Cells (51)
Tag
(4)
C-6xHis (1)
C-6xHis-Avi (1)
C-Flag (1)
C-His (17)
C-His & N-Flag (2)
C-His-Avi (1)
C-hFc (12)
C-mFc (4)
GFP (1)
N-His (2)
N-hFc (3)
Tag Free (6)
Cat No. product name / Synonyms Species Expression System
TMPY-01365 CD97 Protein, Human, Recombinant (His)
CD97 Protein, Human, Recombinant (His)
Human HEK293 Cells
CD97 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.6 kDa and the accession number i...
TMPY-01683 CD97 Protein, Human, Recombinant (hFc)
CD97 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
CD97 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 68.2 kDa and the accession number i...
TMPY-01797 Frizzled 10 Protein, Mouse, Recombinant (hFc)
Frizzled 10 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
Frizzled 10 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession num...
TMPY-01798 Frizzled 10 Protein, Mouse, Recombinant (His)
Frizzled 10 Protein, Mouse, Recombinant (His)
Mouse HEK293 Cells
Frizzled 10 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession n...
TMPY-02037 TSC22D1 Protein, Mouse, Recombinant (His)
TSC22D1 Protein, Mouse, Recombinant (His)
Mouse E. coli
TSC22D1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession nu...
TMPY-02276 GPR56 Protein, Human, Recombinant (His)
GPR56 Protein, Human, Recombinant (His)
Human HEK293 Cells
ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as GPR56) is a Protein Coding gene. GPR56 is a member of an adhesion G protein-coupled receptor family...
TMPY-02400 TSC22D1 Protein, Human, Recombinant (His)
TSC22D1 Protein, Human, Recombinant (His)
Human E. coli
TSC22D1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.2 kDa and the accession nu...
TMPY-02717 GPR37 Protein, Human, Recombinant (His)
GPR37 Protein, Human, Recombinant (His)
Human HEK293 Cells
GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family compris...
TMPY-02837 GPR114 Protein, Human, Recombinant (hFc)
GPR114 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
GPR114 belongs to the G-protein coupled receptor 2 family. Members of this family share a common molecular architecture which consists of seven transmembrane dom...
TMPY-03293 Frizzled 5 Protein, Mouse, Recombinant (hFc)
Frizzled 5 Protein, Mouse, Recombinant (hFc)
Mouse CHO Cells
Frizzled 5 Protein, Mouse, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession numbe...
TMPY-03310 Frizzled 4 Protein, Rat, Recombinant (hFc)
Frizzled 4 Protein, Rat, Recombinant (hFc)
Rat HEK293 Cells
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ...
TMPY-03860 Endothelin B Receptor Protein, Human, Recombinant (mFc)
Endothelin B Receptor Protein, Human, Recombinant (mFc)
Human HEK293 Cells
Endothelin B Receptor Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34.4 kDa and the a...
TMPY-04140 Frizzled 10 Protein, Human, Recombinant (hFc)
Frizzled 10 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
Frizzled 10 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession n...
TMPY-04147 Frizzled 10 Protein, Human, Recombinant (His)
Frizzled 10 Protein, Human, Recombinant (His)
Human HEK293 Cells
Frizzled 10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.5 kDa and the accession n...
TMPY-04270 GPR133 Protein, Human, Recombinant (His)
GPR133 Protein, Human, Recombinant (His)
Human HEK293 Cells
ADGRD1 (Adhesion G Protein-Coupled Receptor D1, also known as GPR133) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. ADGRD1...
TMPY-04271 Frizzled 6 Protein, Human, Recombinant (His)
Frizzled 6 Protein, Human, Recombinant (His)
Human HEK293 Cells
Frizzled 6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession nu...
TMPY-04302 Frizzled 4 Protein, Human, Recombinant (His)
Frizzled 4 Protein, Human, Recombinant (His)
Human HEK293 Cells
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ...
TMPY-04633 Frizzled 2 Protein, Mouse, Recombinant (hFc)
Frizzled 2 Protein, Mouse, Recombinant (hFc)
Mouse HEK293 Cells
FZD2 may be a tumor suppressor gene in salivary adenoid cystic carcinomas (SACCs) that inhibits cell growth and migration. OMOD2 is a rare skeletal dysplasia and...
TMPY-05489 Frizzled 5 Protein, Human, Recombinant (hFc)
Frizzled 5 Protein, Human, Recombinant (hFc)
Human HEK293 Cells
Frizzled 5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession nu...
TMPY-05808 Renin Protein, Human, Recombinant (R66K, His)
Renin Protein, Human, Recombinant (R66K, His)
Human HEK293 Cells
Renin Protein, Human, Recombinant (R66K, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.74 kDa and the accession ...
CD97 Protein, Human, Recombinant (His)
TMPY-01365
CD97 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.6 kDa and the accession number i...
CD97 Protein, Human, Recombinant (hFc)
TMPY-01683
CD97 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 68.2 kDa and the accession number i...
Frizzled 10 Protein, Mouse, Recombinant (hFc)
TMPY-01797
Frizzled 10 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession num...
Frizzled 10 Protein, Mouse, Recombinant (His)
TMPY-01798
Frizzled 10 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession n...
TSC22D1 Protein, Mouse, Recombinant (His)
TMPY-02037
TSC22D1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession nu...
GPR56 Protein, Human, Recombinant (His)
TMPY-02276
ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as GPR56) is a Protein Coding gene. GPR56 is a member of an adhesion G protein-coupled receptor family...
TSC22D1 Protein, Human, Recombinant (His)
TMPY-02400
TSC22D1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.2 kDa and the accession nu...
GPR37 Protein, Human, Recombinant (His)
TMPY-02717
GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family compris...
GPR114 Protein, Human, Recombinant (hFc)
TMPY-02837
GPR114 belongs to the G-protein coupled receptor 2 family. Members of this family share a common molecular architecture which consists of seven transmembrane dom...
Frizzled 5 Protein, Mouse, Recombinant (hFc)
TMPY-03293
Frizzled 5 Protein, Mouse, Recombinant (hFc) is expressed in CHO mammalian cells with hFc tag. The predicted molecular weight is 42.9 kDa and the accession numbe...
Frizzled 4 Protein, Rat, Recombinant (hFc)
TMPY-03310
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ...
Endothelin B Receptor Protein, Human, Recombinant (mFc)
TMPY-03860
Endothelin B Receptor Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 34.4 kDa and the a...
Frizzled 10 Protein, Human, Recombinant (hFc)
TMPY-04140
Frizzled 10 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.8 kDa and the accession n...
Frizzled 10 Protein, Human, Recombinant (His)
TMPY-04147
Frizzled 10 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.5 kDa and the accession n...
GPR133 Protein, Human, Recombinant (His)
TMPY-04270
ADGRD1 (Adhesion G Protein-Coupled Receptor D1, also known as GPR133) is a Protein Coding gene. 4 alternatively spliced human isoforms have been reported. ADGRD1...
Frizzled 6 Protein, Human, Recombinant (His)
TMPY-04271
Frizzled 6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession nu...
Frizzled 4 Protein, Human, Recombinant (His)
TMPY-04302
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ...
Frizzled 2 Protein, Mouse, Recombinant (hFc)
TMPY-04633
FZD2 may be a tumor suppressor gene in salivary adenoid cystic carcinomas (SACCs) that inhibits cell growth and migration. OMOD2 is a rare skeletal dysplasia and...
Frizzled 5 Protein, Human, Recombinant (hFc)
TMPY-05489
Frizzled 5 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 42.7 kDa and the accession nu...
Renin Protein, Human, Recombinant (R66K, His)
TMPY-05808
Renin Protein, Human, Recombinant (R66K, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.74 kDa and the accession ...
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TargetMol