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G Protein-Coupled Receptors, GPCRs

G protein-coupled receptors (GPCRs) form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. GPCRs are found only in eukaryotes, including yeast, and choanoflagellates. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters.

GPCRs are involved in many diseases such as mental, metabolic including endocrinological disorders, immunological including viral infections, cardiovascular, inflammatory, senses disorders, and cancer. Therefore, GPCRs are an important drug target and approximately 34% of all Food and Drug Administration (FDA) approved drugs target 108 members of this family.

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Species
Cynomolgus (2)
Human (41)
Mouse (10)
Rat (2)
Expression System
Baculovirus-Insect Cells (1)
CHO (1)
E. coli (2)
HEK293 (47)
Human Cells (4)
Tag
(4)
AVI (1)
C-6His (1)
C-6His-Avi (1)
C-Fc (1)
C-hFc (2)
C-mFc (2)
FLAG (2)
Flag (1)
GFP (1)
His (22)
N-Fc (1)
Tag Free (6)
hFc (11)
mFc (2)
Cat No. product name / Synonyms Species Expression System
TMPJ-00354 FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)
FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)
Mouse Human Cells
Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signaling by serving as a co-receptor w...
TMPJ-01037 CXCR4 Protein, Human, Recombinant (hFc)
CXCR4 Protein, Human, Recombinant (hFc)
Human Human Cells
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with ...
TMPJ-01331 Frizzled-8 Protein, Human, Recombinant (His & Avi), Biotinylated
Frizzled-8 Protein, Human, Recombinant (His & Avi), Biotinylated
Human Human Cells
Frizzled-8 is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein-...
TMPJ-01332 Frizzled-8 Protein, Human, Recombinant (His)
Frizzled-8 Protein, Human, Recombinant (His)
Human Human Cells
Frizzled-8 is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein-...
TMPK-00528 GPRC5D Protein-VLP, Cynomolgus, Recombinant
GPRC5D Protein-VLP, Cynomolgus, Recombinant
Cynomolgus HEK293
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orph...
TMPK-00743 LGR-5 Protein, Human, Recombinant (hFc)
LGR-5 Protein, Human, Recombinant (hFc)
Human HEK293
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a thera...
TMPK-00861 A2AR Protein-VLP, Human, Recombinant
A2AR Protein-VLP, Human, Recombinant
Human HEK293
Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound receptors for adenosine have been identified and cDNAs for A1, A2a, A2b, and A3...
TMPK-00879 CCR2b Protein-VLP, Human, Recombinant
CCR2b Protein-VLP, Human, Recombinant
Human HEK293
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant...
TMPK-00896 CCR8 Protein, Human, Recombinant (hFc)
CCR8 Protein, Human, Recombinant (hFc)
Human HEK293
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al...
TMPK-00897 CCR8 Protein, Human, Recombinant (mFc)
CCR8 Protein, Human, Recombinant (mFc)
Human HEK293
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al...
TMPK-01193 GPRC5D Protein-VLP, Mouse, Recombinant
GPRC5D Protein-VLP, Mouse, Recombinant
Mouse HEK293
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orph...
TMPK-01316 CCR8 Protein, Cynomolgus, Recombinant (mFc)
CCR8 Protein, Cynomolgus, Recombinant (mFc)
Cynomolgus HEK293
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al...
TMPY-00085 Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc)
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc)
Human HEK293
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 42.1 kDa. Accession number...
TMPY-00181 Endothelin B Receptor Protein, Human, Recombinant (His)
Endothelin B Receptor Protein, Human, Recombinant (His)
Human HEK293
The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a...
TMPY-00197 Frizzled 4 Protein, Human, Recombinant (hFc)
Frizzled 4 Protein, Human, Recombinant (hFc)
Human HEK293
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ...
TMPY-00313 Frizzled 4 Protein, Rat, Recombinant (His)
Frizzled 4 Protein, Rat, Recombinant (His)
Rat HEK293
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ...
TMPY-00317 Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)
Human HEK293
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 43.9 kDa. Accession numbe...
TMPY-00577 Frizzled 6 Protein, Human, Recombinant (mFc)
Frizzled 6 Protein, Human, Recombinant (mFc)
Human HEK293
FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolat...
TMPY-01165 FZD1/Frizzled 1 Protein, Mouse, Recombinant (His)
FZD1/Frizzled 1 Protein, Mouse, Recombinant (His)
Mouse HEK293
Frizzled-1, also known as FZD1, belongs to theG-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal ...
TMPY-01231 Renin Protein, Mouse, Recombinant (His)
Renin Protein, Mouse, Recombinant (His)
Mouse HEK293
Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of...
FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)
TMPJ-00354
Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signaling by serving as a co-receptor w...
CXCR4 Protein, Human, Recombinant (hFc)
TMPJ-01037
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with ...
Frizzled-8 Protein, Human, Recombinant (His & Avi), Biotinylated
TMPJ-01331
Frizzled-8 is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein-...
Frizzled-8 Protein, Human, Recombinant (His)
TMPJ-01332
Frizzled-8 is one of at least ten seven-transmembrane (7TM) glycoproteins of the Frizzled family of Wnt receptors. Frizzled proteins are thought to be G-protein-...
GPRC5D Protein-VLP, Cynomolgus, Recombinant
TMPK-00528
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orph...
LGR-5 Protein, Human, Recombinant (hFc)
TMPK-00743
G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a thera...
A2AR Protein-VLP, Human, Recombinant
TMPK-00861
Adenosine is a neuromodulator in the adult central nervous system. Membrane-bound receptors for adenosine have been identified and cDNAs for A1, A2a, A2b, and A3...
CCR2b Protein-VLP, Human, Recombinant
TMPK-00879
The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant...
CCR8 Protein, Human, Recombinant (hFc)
TMPK-00896
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al...
CCR8 Protein, Human, Recombinant (mFc)
TMPK-00897
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al...
GPRC5D Protein-VLP, Mouse, Recombinant
TMPK-01193
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orph...
CCR8 Protein, Cynomolgus, Recombinant (mFc)
TMPK-01316
CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in al...
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc)
TMPY-00085
Calcitonin receptor Protein, Human, Recombinant (aa 1-153, hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 42.1 kDa. Accession number...
Endothelin B Receptor Protein, Human, Recombinant (His)
TMPY-00181
The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a...
Frizzled 4 Protein, Human, Recombinant (hFc)
TMPY-00197
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ...
Frizzled 4 Protein, Rat, Recombinant (His)
TMPY-00313
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known ...
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)
TMPY-00317
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 with hFc tag. The predicted molecular weight is 43.9 kDa. Accession numbe...
Frizzled 6 Protein, Human, Recombinant (mFc)
TMPY-00577
FZD6 plays a pivotal role in the growth and guidance of the nail plate in humans by acting as a molecular switch between different Wnt pathways. Inherited isolat...
FZD1/Frizzled 1 Protein, Mouse, Recombinant (His)
TMPY-01165
Frizzled-1, also known as FZD1, belongs to theG-protein coupled receptor Fz/Smo family. FZD1 contains a signal peptide, a cysteine-rich domain in the N-terminal ...
Renin Protein, Mouse, Recombinant (His)
TMPY-01231
Renin-1, also known as Ren-1, Angiotensinogenase and Kidney renin, is a member of the peptidase A1 family. Renin-1 is synthesized by the juxtaglomerular cells of...
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TargetMol