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alpha-D-glucose

Name: alpha-D-glucose
Brand: TargetMol
SKU: T4884
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4884Cas No. 492-62-6

Alias α-D-Glucose, α-Dextrose, alpha-Glucose

alpha-D-glucose (α-Dextrose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.

alpha-D-glucose

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Purity: 99.87%

Catalog No. T4884Alias α-D-Glucose, α-Dextrose, alpha-GlucoseCas No. 492-62-6

Pack Size	Price	USA Warehouse	Global Warehouse
50 mg	$33	In Stock	In Stock
100 mg	$48	In Stock	In Stock
500 mg	$107	In Stock	In Stock
1 g	$156	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$54	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.87%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

alpha-D-glucose AI Summary

alpha-D-glucose shows a broad spectrum of bioactivities. It has very low partition coefficients, with logP values below -3, indicating a preference for partitioning into water over dodecane. In terms of its biochemical interactions, alpha-D-glucose demonstrates competitive inhibition of rabbit muscle glycogen phosphorylase b with a Ki value of 1,700,000.0 nM and has additional inhibitory effects on liver glycogen phosphorylase a, with Ki values ranging up to 4,900,000.0 nM. The compound also promotes [1-3H]-2-deoxy-D-glucose uptake in 3T3 L1 adipocytes, with observed activity of 34.0 Bq. In antiviral assays, alpha-D-glucose inhibits SARS-CoV-2 induced cytotoxicity of Caco-2 cells at a 10 uM concentration after 48 hours with an inhibition rate of 32.8%, though other assays showed a lower inhibition rate of 12.57% on SARS-CoV-2 3CL-Pro protease activity at a 20 µM concentration. Additionally, it interacts with calf thymus DNA, displacing EtBr with a C50 of 390.0 uM, and significantly increases the melting temperature of the DNA-ligand complex by 10.3°C. Furthermore, it shows inhibitory activities against human HDAC6, with inhibition percentages of -23.98% and -14.18% using different peptide substrates. These diverse bioactivities suggest potential applications in enzyme inhibition, antiviral therapy, and modulation of DNA-protein interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	alpha-D-glucose (α-Dextrose) is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
Synonyms	α-D-Glucose, α-Dextrose, alpha-Glucose

Chemical Properties

Molecular Weight	180.16
Formula	C₆H₁₂O₆
Cas No.	492-62-6
Smiles	C(O)[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O)O1
Relative Density.	1.544g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (249.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	5.5506 mL	27.7531 mL	55.5062 mL	277.5311 mL
5 mM	1.1101 mL	5.5506 mL	11.1012 mL	55.5062 mL
10 mM	0.5551 mL	2.7753 mL	5.5506 mL	27.7531 mL
20 mM	0.2775 mL	1.3877 mL	2.7753 mL	13.8766 mL
50 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
100 mM	0.0555 mL	0.2775 mL	0.5551 mL	2.7753 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc