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Zinc pyrithione

Catalog No. T0502 CAS 13463-41-7

Synonyms: OM-1563

Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.

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Zinc pyrithione, CAS 13463-41-7

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500 mg	In stock	$ 45.00
1 g	In stock	$ 55.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.64%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Zinc pyrithione (OM-1563), an antibacterial and antifungal agent can disrupt membrane transport by blocking the proton pump.
In vitro	In exposed mussel tissues, Zinc pyrithione accumulates rapidly, with the rate of accumulation being proportional to both exposure concentration and time. Despite a 7-day LC50 (lethal concentration for 50% of the population) of 8.27 μM in relatively higher concentrations of Zinc pyrithione, this indicates a potential threat to coastal ecosystems and marine life, necessitating further investigation into its sub-lethal biological effects.
In vivo	As a specific synthetic potentiator, Zinc pyrithione activates homotypic and heterotypic M channels by inducing a resting potential. It is considered a zinc complex. The Pyrithione ligand (formally a monoanion) chelates with Zn2+ through oxygen and iron-sulfur centers. In the crystalline state, Zinc pyrithione exists as a centrosymmetric dimer, with each zinc atom coordinated to two sulfur and three oxygen centers. However, in solution, the dimers dissociate through the cleavage of zinc-oxygen bonds. Although Zinc pyrithione is a dimer, its activity causing cytoplasmic membrane depolarization may originate from the monomer, with an effective concentration for half-maximum effect (K1/2) of approximately 0.3 mM.

Synonyms	OM-1563
Molecular Weight	317.71
Formula	C10H8N2O2S2Zn
CAS No.	13463-41-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 28 mg/mL (88.1 mM)

References and Literature

1. Ermolayeva E, et al. Appl Environ Microbiol, 1995, 61(9), 3385-3390. 2. Xiong Q, et al. Nat Chem Biol, 2007, 3(5), 287-296. 3. Marcheselli M, et al. Environ Toxicol Chem, 2010, 29(11), 2583-2592.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Drug Repurposing Compound Library Exosome Compound Library Bioactive Compounds Library Max Bioactive Compound Library Anti-Infection Compound Library FDA-Approved Drug Library Anti-Cardiovascular Disease Compound Library

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Keywords

Zinc pyrithione 13463-41-7 Membrane transporter/Ion channel Microbiology/Virology Antibacterial Antifungal Proton pump Bacterial inhibit Inhibitor OM-1563 Proton Pump OM1563 Fungal OM 1563 inhibitor

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