Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 128.00 | |
5 mg | In stock | $ 272.00 | |
10 mg | In stock | $ 455.00 | |
25 mg | In stock | $ 753.00 | |
50 mg | In stock | $ 1,050.00 | |
100 mg | In stock | $ 1,420.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 297.00 |
Description | Zegocractin (CM-4620) is a calcium-release activated calcium-channel (CRAC channel) inhibitor. |
Targets&IC50 | Orai2/STIM1:119 nM, Orai2/STIM1:895 nM |
In vitro | CM-4620 (compound 1) is more potent on Orai1 than Orai2-type CRAC channels. In human PBMCs, CM-4620 potently inhibits release of multiple cytokines which play important roles in T cells (IC50s, IFN γ: 138 nM, IL-6: 135 nM, IL-4: 879 nM, IL-1β: 240 nM, IL-10: 303 nM, IL-2: 59 nM, TNFα: 225 nM, IL-17 120 nM) [1]. |
In vivo | Mouse PACs are treated with CRAC inhibitors GSK-7975A or CM-4620 and monitored for their rate of Calcium uptake. Both CRAC inhibitors reduce the rate of store-operated Calcium entry into the ER to 50% of control levels upon treatment with 700 nM of inhibitor. CM-4620 blocks 100% of the reuptake at 10 mM. |
Synonyms | CM-4620, N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide, CM4620 |
Molecular Weight | 421.76 |
Formula | C19H11ClF3N3O3 |
CAS No. | 1713240-67-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 100 mg/mL (237.10 mM)
You can also refer to dose conversion for different animals. More
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Zegocractin 1713240-67-5 Membrane transporter/Ion channel Metabolism Calcium Channel Inhibitor inhibit CM 4620 Calcium release-activated channels Ca2+ release-activated Ca2+ channels CRAC Channel CM-4620 N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide CM4620 inhibitor