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Z-VAD-FMK

Catalog No. T7020   CAS 161401-82-7
Synonyms: Z-VAD(OH)-FMK, Caspase Inhibitor VI, Z-VAD

Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Z-VAD-FMK Chemical Structure
Z-VAD-FMK, CAS 161401-82-7
Pack Size Availability Price/USD Quantity
1 mg In stock
$ 121.00
$ 96.80
5 mg In stock
$ 257.00
$ 205.60
10 mg In stock
$ 438.00
$ 350.40
25 mg In stock
$ 696.00
$ 556.80
1 mL * 10 mM (in DMSO) In stock
$ 283.00
$ 226.40
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Purity: 99.44%
Purity: 98.63%
Purity: 98.24%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
In vitro Z-VAD(OH)-FMK is the non-methylated form of Z-VAD-FMK, and useful in studies including recombinant, or purified enzymes. [1]
Synonyms Z-VAD(OH)-FMK, Caspase Inhibitor VI, Z-VAD
Molecular Weight 453.46
Formula C21H28FN3O7
CAS No. 161401-82-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: <1 mg/mL

Ethanol: 83 mg/mL (183 mM)

DMSO: 83 mg/mL (183 mM)

TargetMolReferences and Literature

1. Garcia-Calvo M, et al. J Biol Chem. 1998, 273(49), 32608-32613. 2. Xue J, Gruber F, Tschachler E, et al. Crosstalk between oxidative stress, autophagy and apoptosis in Hemoporfin Photodynamic Therapy treated human umbilical vein endothelial cells[J]. Photodiagnosis and Photodynamic Therapy. 2020: 102137. 3. Sun Y, He L, Wang T, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells[J]. Molecular Neurobiology. 2020, 57(11): 4628-4641.

TargetMolCitations

1. Yan C, Zheng L, Jiang S, et al.Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity.Cancer Cell.2023 2. Hu G, Cui Z, Chen X, et al.Suppressing Mesenchymal Stromal Cell Ferroptosis Via Targeting a Metabolism‐Epigenetics Axis Corrects their Poor Retention and Insufficient Healing Benefits in the Injured Liver Milieu.Advanced Science.2023: 2206439. 3. Wang X, Ji Y, Qi J, et al.Mitochondrial carrier 1 (MTCH1) governs ferroptosis by triggering the FoxO1-GPX4 axis-mediated retrograde signaling in cervical cancer cells.Cell Death & Disease.2023, 14(8): 1-13. 4. Zhu X, Huang N, Ji Y, et al.Brusatol induces ferroptosis in oesophageal squamous cell carcinoma by repressing GSH synthesis and increasing the labile iron pool via inhibition of the NRF2 pathway.Biomedicine & Pharmacotherapy.2023, 167: 115567. 5. Qiu C, Shen X, Lu H, et al.Combination therapy with HSP90 inhibitors and piperlongumine promotes ROS-mediated ER stress in colon cancer cells.Cell Death Discovery.2023, 9(1): 375. 6. Huang F, Liang J, Lin Y, et al.Repurposing of Ibrutinib and Quizartinib as potent inhibitors of necroptosis.Communications Biology.2023, 6(1): 972. 7. Shao H, Xu L, Li G, et al.Analysis on benzothiazole necroptosis inhibitors with chiral substitutions in the solvent-accessible region of RIP kinase domain.Bioorganic Chemistry.2023: 106647. 8. Zeng H, Xie H, Ma Q, et al.Identification of N-(3-(methyl (3-(orotic amido) propyl) amino) propyl) oleanolamide as a novel topoisomerase I catalytic inhibitor by rational design, molecular dynamics simulation, and biological evaluation.Bioorganic Chemistry.2023: 106734. 9. Sun Y, Xu L, Shao H, et al. Discovery of a Trifluoromethoxy Cyclopentanone Benzothiazole Receptor-Interacting Protein Kinase 1 Inhibitor as the Treatment for Alzheimer’s Disease. Journal of Medicinal Chemistry. 2022 10. Xue J, Gruber F, Tschachler E, et al. Crosstalk between oxidative stress, autophagy and apoptosis in Hemoporfin Photodynamic Therapy treated human umbilical vein endothelial cells. Photodiagnosis and Photodynamic Therapy. 2020: 102137.
11. Su G, Yang W, Wang S, et al. SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18. Biochemical and Biophysical Research Communications. 2021, 561: 33-39. 12. Ning X, Qi H, Yuan Y, et al. Identification of a new small molecule that initiates ferroptosis in cancer cells by inhibiting the system Xc− to deplete GSH. European Journal of Pharmacology. 2022: 175304. 13. Wang F, Xie M, Chen P, et al. Homoharringtonine combined with cladribine and aclarubicin (HCA) in acute myeloid leukemia: A new regimen of conventional drugs and its mechanism. Oxidative Medicine and Cellular Longevity. 2022 14. Wang S, Wang Z, Wang X, et al. Humanized cerebral organoids-based ischemic stroke model for discovering of potential anti-stroke agents. Acta Pharmacologica Sinica. 2022: 1-11. 15. Sun Y, He L, Wang T, et al. Activation of p62-Keap1-Nrf2 Pathway Protects 6-Hydroxydopamine-Induced Ferroptosis in Dopaminergic Cells. Molecular Neurobiology. 2020, 57(11): 4628-4641. 16. Tschuck J, Theilacker L, Rothenaigner I, et al.Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis.Nature Communications.2023, 14(1): 6908. 17. Tian T, Xie X, Yi W, et al.FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation.Cell Reports.2023, 42(11). 18. Wu X, Yi X, Zhao B, et al.The volume regulated anion channel VRAC regulates NLRP3 inflammasome by modulating itaconate efflux and mitochondria function.Pharmacological Research.2023: 107016. 19. Liu S, Tao Y, Wu S, et al.Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer.Chinese Medicine.2024, 19(1): 1-18. 20. Chen H, Hu J, Xiong X, et al.AURKA inhibition induces Ewing’s sarcoma apoptosis and ferroptosis through NPM1/YAP1 axis.Cell Death & Disease.2024, 15(1): 99. 21. Tao Y, Lu J, Li L, et al.Raltitrexed induces apoptosis through activating ROS-mediated ER stress by impeding HSPA8 expression in prostate cancer cells.Biochimica et Biophysica Acta (BBA)-Molecular Cell Research.2024: 119684. 22. Li J, Liu X, Liu Y, et al.Saracatinib inhibits necroptosis and ameliorates psoriatic inflammation by targeting MLKL.Cell Death & Disease.2024, 15(2): 122.
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Related compound libraries

This product is contained In the following compound libraries:
Highly Selective Inhibitor Library Anti-Aging Compound Library Bioactive Compound Library Anti-Cancer Compound Library Bioactive Compounds Library Max NO PAINS Compound Library

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Keywords

Z-VAD-FMK 161401-82-7 Apoptosis Proteases/Proteasome Caspase inhibit Inhibitor ZVADFMK Hela Z VAD FMK Antiapoptosis cells pan-caspase Z-VAD(OH)-FMK Caspase Inhibitor VI Z-VAD inhibitor

 

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