Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
Description | Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
In vitro | Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1]. |
Cell Research | Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour. |
Synonyms | FAK Inhibitor 14, 1,2,4,5-苯四胺四盐酸盐, 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK inhibitor Y15 |
Molecular Weight | 284.01 |
Formula | C6H14Cl4N4 |
CAS No. | 4506-66-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: 59 mg/mL (207.74 mM), Need ultrasonic and warming
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Y15 4506-66-5 蛋白酪氨酸激酶 细胞骨架 血管生成 FAK PTK2 protein tyrosine kinase 2 FAK Inhibitor-14 FAK Inhibitor14 Y 15 FAK inhibitor Y15 PTK2 Focal adhesion kinase 1,2,4,5-Benzenetetramine tetrahydrochlor Y-15 FAK Inhibitor 14 Inhibitor inhibit inhibitor