Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Xanomeline oxalate (LY246708 oxalate), a potent and selective muscarinic receptor agonist (SMRA), effectively stimulates in vivo phosphoinositide hydrolysis. It is a valuable compound for Alzheimer's disease research.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 53.00 | |
10 mg | In stock | $ 89.00 | |
25 mg | In stock | $ 178.00 | |
50 mg | In stock | $ 285.00 | |
100 mg | In stock | $ 453.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 59.00 |
Description | Xanomeline oxalate (LY246708 oxalate), a potent and selective muscarinic receptor agonist (SMRA), effectively stimulates in vivo phosphoinositide hydrolysis. It is a valuable compound for Alzheimer's disease research. |
In vitro | Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells. Xanomeline inhibits [3H]-pirenzepine ([3H]-PZ) and [3H]-oxotremorine-M ([3H]-OXO-M) binding to rat brain with Kis of 7 and 3 nM, respectively[1]. |
In vivo | Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 8.1 μmole/kg in hippocampus[1]. |
Synonyms | LY246708 oxalate |
Molecular Weight | 371.45 |
Formula | C16H25N3O5S |
CAS No. | 141064-23-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45mg/mL (121.1mM)
You can also refer to dose conversion for different animals. More
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Xanomeline oxalate 141064-23-5 Neuroscience AChR LY246708 oxalate Xanomeline Oxalate LY246708 Oxalate LY-246708 Oxalate LY 246708 Oxalate inhibitor inhibit