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Taurolidine

Catalog No. T7533 CAS 19388-87-5

Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.

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Taurolidine, CAS 19388-87-5

Pack Size	Availability	Price/USD
25 mg	In stock	$ 47.00
50 mg	In stock	$ 74.00
100 mg	In stock	$ 113.00
200 mg	In stock	$ 168.00
500 mg	In stock	$ 283.00
1 mL * 10 mM (in DMSO)	In stock	$ 29.00

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Purity: 98%

Biological Description

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Description	Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. It displays broad bactericidal and fungicidal activity.
In vitro	Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml.?A dose-dependent decrease in cell viability was also observed[1].
In vivo	In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals)[1].
Cell Research	In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine.?Cells incubated in culture medium alone were used as controls.?Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques[1].
Animal Research	In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group).?Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS).?Group B received Taurolidine (100 mg/kg) instead of PBS.?Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity[1].

Molecular Weight	284.36
Formula	C7H16N4O4S2
CAS No.	19388-87-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56mg/mL(196.93mM)

References and Literature

1. Mccourt M , Wang J H , Sookhai S , et al. Taurolidine Inhibits Tumor Cell Growth In Vitro and In Vivo[J]. Annals of Surgical Oncology, 2000, 7(9):685-691. 2. Madeline, Fink, Abdulla, et al. Taurolidine Sensitivity of Eryptosis, the Suicidal Erythrocyte Death.[J]. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Approved Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Approved Drug Library Bioactive Compound Library NO PAINS Compound Library Apoptosis Compound Library Anti-Colorectal Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Taurolidine 19388-87-5 Apoptosis Microbiology/Virology Others Antibacterial Antibiotic antiseptic CVC Inhibitor inhibit antimicrobial catheters central CRBSI catheter-related infections venous Bacterial inhibitor

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