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Salidroside

Catalog No. T2717 CAS 10338-51-9

Synonyms: Rhodioloside

Salidroside (Rhodioloside) is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl endopeptidase Inhibitor.

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Salidroside, CAS 10338-51-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 52.00
10 mg	In stock	$ 85.00
25 mg	In stock	$ 142.00
50 mg	In stock	$ 208.00
100 mg	In stock	$ 313.00
500 mg	In stock	$ 748.00
1 mL * 10 mM (in DMSO)	In stock	$ 64.00

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Purity: 99.25%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Salidroside (Rhodioloside) is a bioactive phenolic glycoside compound isolated from Rhodiola crenulata. It is a prolyl endopeptidase Inhibitor.
In vitro	Salidroside, at dosages of 20, 50, and 100 mg/kg, protects liver tissue from oxidative stress induced by D-galactosamine and LPS (lipopolysaccharide).
In vivo	Salidroside induces cell cycle arrest at the G1 and G2 phases in various cancer cell lines, while concurrently decreasing levels of CDK4, cyclin D1, cyclin B1, and Cdc2, and upregulating p27(Kip1) and p21(Cip1). Its concentration and time-dependent properties inhibit the growth of diverse human cancer cell lines. Salidroside activates the PI3K/Akt pathway, offering protection against MPP(+)-induced apoptosis in PC12 cells, presenting a potential treatment for Parkinson's Disease (PD). Additionally, by activating the ERK1/2 pathway and inhibiting caspase-3 activation, salidroside reduces cell viability loss and apoptotic cell death in H2O2-stimulated, NGF-differentiated PC12 cells.
Source	Natural Products > Crassulaceae > Rhodiola

Synonyms	Rhodioloside
Molecular Weight	300.3
Formula	C14H20O7
CAS No.	10338-51-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 56 mg/mL (186.5 mM)

Ethanol: 4 mg/mL (13.32 mM)

H2O: 55 mg/mL (183.2 mM)

References and Literature

1. Hu X, et al. Cell Biol Toxicol, 2010, 26(6), 499-507. 2. Yu S, et al. J Mol Neurosci, 2010, 40(3), 321-331. 3. Zhang L, et al. Food Chem Toxicol, 2012, 50(8), 2591-2597. 4. Wu YL, et al. J Pharm Pharmacol, 2009, 61(10), 1375-1382. 6. Ju L, et al. Salidroside, A Natural Antioxidant, Improves β-Cell Survival and Function via Activating AMPK Pathway. Front Pharmacol. 2017 Oct 18;8:749. 7. Wu L, et al. Salidroside Protects against MPP+-Induced Neuronal Injury through DJ-1-Nrf2 Antioxidant Pathway. Evid Based Complement Alternat Med. 2017;2017:5398542.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Miao medicine Compound Library Anti-Neurodegenerative Disease Compound Library Antidepressant Compound Library Neural Regeneration Compound Library Anti-Breast Cancer Compound Library Anti-Diabetic Compound Library Anti-Prostate Cancer Compound Library Anti-Tumor Natural Product Library

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Keywords

Salidroside 10338-51-9 Apoptosis PI3K/Akt/mTOR signaling mTOR POP Inhibitor inhibit Prolyl Endopeptidase (PREP) prolyl oligopeptidase Rhodioloside Mammalian target of Rapamycin inhibitor

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