Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 67.00 | |
25 mg | In stock | $ 147.00 | |
50 mg | In stock | $ 257.00 | |
100 mg | In stock | $ 457.00 | |
500 mg | In stock | $ 987.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 52.00 |
Description | Salermide is an inhibitor of Sirt1 and Sirt2, causing strong cancer-specific apoptotic cell death. |
In vitro | Salermide prompts tumour-specific cell death in a wide range of human cancer cell lines. The antitumour activity of Salermide is primarily because of a massive induction of apoptosis. Salermide induces apoptosis in cancer but not in normal cells. It induces strong apoptosis without any evident effect on the cell cycle in all the cancer cell lines analysed except in non-tumorigenic MRC5 cells. The induction of apoptosis is cell-type-specific and dose-dependent[1]. |
In vivo | Salermide is well tolerated by mice at concentrations up to 100?μM. Its feeding does not produce any adverse health effects in mice as monitored by diet consumption, body-weight gain, and postural and behavioural changes[1]. |
Cell Research | Cell viability is determined using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay as described earlier. IC50 index is calculated using four Salermide concentrations (25, 50, 75 and 100?μm) for 24?h. The percentage of apoptotic cells is determined with the FACSCalibur apparatus.(Only for Reference) |
Molecular Weight | 394.47 |
Formula | C26H22N2O2 |
CAS No. | 1105698-15-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 39.5 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Salermide 1105698-15-4 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor inhibit inhibitor