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SU4984

Catalog No. T9030 CAS 186610-89-9

SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).

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SU4984, CAS 186610-89-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).
Targets&IC50	FGFR1:10-20 μM (IC50)

Molecular Weight	333.391
Formula	C20H19N3O2
CAS No.	186610-89-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ma Y , Al E . Indolinone Derivatives Inhibit Constitutively Activated KIT Mutants and Kill Neoplastic Mast Cells[J]. Journal of Investigative Dermatology, 2000, 114( 2):392-394.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Angiogenesis related Compound Library Bioactive Compound Library Tyrosine Kinase Inhibitor Library

Related Products

Related compounds with same targets

EGFR-IN-16 Dovitinib Dilactic Acid Brivanib Dovitinib (TKI258) Lactate S49076 HCl FIIN-4 ZM323881 hydrochloride Rogaratinib

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SU4984 186610-89-9 蛋白酪氨酸激酶血管生成 FGFR IGF-1R PDGFR inhibit growth Fibroblast growth factor receptor Insulin Receptor fibroblast insulin SU 4984 FGFR1 factor Platelet-derived growth factor receptor SU-4984 kinase tyrosine platelet cancer Inhibitor inhibitor

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