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SKF 38393 hydrochloride

Catalog No. T6988 CAS 62717-42-4

Synonyms: (±)-SKF-38393 hydrochloride, SKF-38393A, SKF38393 HCl

SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

SKF 38393 hydrochloride Chemical Structure

SKF 38393 hydrochloride, CAS 62717-42-4

Pack Size	Availability	Price/USD
25 mg	In stock	$ 50.00
50 mg	In stock	$ 71.00
1 mL * 10 mM (in DMSO)	In stock	$ 78.00

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Purity: 99.1%

Purity: 98.70%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1/D5 receptor agonist.
Targets&IC50	D1:110 nM
In vitro	SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. [1] In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. [2] In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. [4]
In vivo	SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. [3] In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. [5]

Synonyms	(±)-SKF-38393 hydrochloride, SKF-38393A, SKF38393 HCl
Molecular Weight	291.77
Formula	C16H17NO2·HCl
CAS No.	62717-42-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 6 mg/mL(20.56 mM), Heating is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 54 mg/mL (185.1 mM)

References and Literature

1. Huang YY, et al. Proc Natl Acad Sci U S A. 1995, 92(7), 2446-2450. 2. Gorelova NA, et al. J Neurophysiol. 2000, 84(1), 75-87. 3. Amico F, et al. Eur J Pharmacol. 2007, 577(1-3), 71-77. 4. Reichenbach N, et al. Proteome Sci. 2015, 13, 13. 5. Nasehi M, et al. Psychopharmacology (Berl). 2016, 233(2), 213-224.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Membrane Protein-targeted Compound Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Antidepressant Compound Library Anti-Parkinson's Disease Compound Library Anti-Cancer Compound Library Anti-Alzheimer's Disease Compound Library Endocrinology-Hormone Compound Library Preclinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

SKF 38393 hydrochloride 62717-42-4 GPCR/G Protein Neuroscience Dopamine Receptor SKF 38393 Hydrochloride SKF 38393 SKF-38393 inhibit Inhibitor SKF38393 (±)-SKF-38393 hydrochloride SKF-38393A SKF38393 Hydrochloride SKF-38393 Hydrochloride SKF38393 HCl inhibitor

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