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Quinine hydrochloride dihydrate

Catalog No. T6631 CAS 6119-47-7

Synonyms: Quinine HCl Dihydrate

Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.

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Quinine hydrochloride dihydrate Chemical Structure

Quinine hydrochloride dihydrate, CAS 6119-47-7

Pack Size	Availability	Price/USD	Quantity
1 g	In stock	$ 29.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.04%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.

In vitro

Quinine blocks Cx36 and Cx50 junctional currents in a reversible and concentration-dependent manner with half maximal blocking concentrations of 32 mM and 73 mM, respectively. Quinine induces slow transitions between open and fully closed states that decreased open probability of the channel. Quinine thus offers a potentially useful method to block certain types of gap junction channels, including those between neurons that are formed by Cx36. [1] Quinine, a K+ channel blocker, prevents formation of tumor necrosis factor (TNF) as well as the subsequent hepatic DNA fragmentation and liver enzyme leakage. [2] Quinine elicits Fos-like immunoreactivity (FLI) concentrated in the medial third of the nucleus; acid elicited more broadly distributed FLI concentrated farther laterally. [3] Quinine has a relatively weak effect on doxorubicin accumulation but was able to completely restore doxorubicin sensitivity in the resistant cells. Quinine also modifies the intracellular tolerance to doxorubicin, which suggests that it is able to modify drug distribution within the cells. [4] Quinine primarily blocks the whole cell potassium currents (IK) in a voltage-dependent manner. Quinine also reduces the size of sodium currents (INa) in a use-dependent manner, while leaving calcium currents (ICa) relatively unaffected. [5]

Synonyms	Quinine HCl Dihydrate
Molecular Weight	396.91
Formula	C20H24N2O2·HCl·2H2O
CAS No.	6119-47-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 79 mg/mL (199.03 mM)

Ethanol: 79 mg/mL (199.03 mM)

H2O: 43 mg/mL (108.33 mM)

References and Literature

1. Srinivas M, et al. Proc Natl Acad Sci U S A,2001, 98(19), 10942-10947. 2. Gantner F, et al. Eur J Pharmacol,1995, 294(1), 353-355. 3. Travers SP, et al. Am J Physiol Regul Integr Comp Physiol,2002, 282(6), R1798-1810. 4. Bennis S, et al. Int J Cancer,1995, 62(3), 283-290. 5. Lin X, et al. J Neurophysiol,1998, 79(5), 2503-2512.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Parasitic Compound Library Antiparasitic Natural Product Library Anti-Cancer Approved Drug Library Traditional Chinese Medicine Monomer Library Anti-Cancer Drug Library Membrane Protein-targeted Compound Library Drug Repurposing Compound Library Selected Plant-Sourced Compound Library Alkaloid Natural Product Library Potassium Channel Blocker Library

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ZM 226600 Phenformin hydrochloride E-4031 Mitiglinide calcium hydrate (-)-Denudatin B PAP-1 Nifekalant hydrochloride O-Nornuciferine

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Keywords

Quinine hydrochloride dihydrate 6119-47-7 Membrane transporter/Ion channel Microbiology/Virology Parasite Potassium Channel Quinine Hydrochloride Quinine HCl inhibit anti-malarial cinchonaine Inhibitor Quinine hydrochloride Dihydrate Quinine Quinine HCl Dihydrate KcsA inhibitor

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