Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 57.00 | |
5 mg | In stock | $ 81.00 | |
10 mg | In stock | $ 138.00 | |
25 mg | In stock | $ 307.00 | |
50 mg | In stock | $ 547.00 | |
100 mg | In stock | $ 578.00 | |
200 mg | In stock | $ 827.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 92.00 |
Description | PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a selective, and orally active Kv1.3 blocker (EC50: 2 nM). |
Targets&IC50 | Kv1.5:45 nM (EC50), Kv1.3:2 nM (EC50) |
In vitro | PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50: 45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels [1, 2]. PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells (IC50: 10 nM) [1]. |
In vivo | PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats [1]. |
Cell Research | Cell Line: CCR7-TEM cells (anti-CD3 Ab stimulated). Concentration: 2, 10, 25, 100 nM. Incubation Time: 30 minutes [1] |
Animal Research | Animal Model: 9- to 11- week-old female Lewis rats. Dosage: I.P.; three times daily for 48 hours. Administration: 0.3, 1, 3 mg/kg [1] |
Synonyms | 5-(4-Phenoxybutoxy)psoralen |
Molecular Weight | 350.36 |
Formula | C21H18O5 |
CAS No. | 870653-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (137 mM), sonification is recommended.
H2O: Insoluble
You can also refer to dose conversion for different animals. More
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PAP-1 870653-45-5 Membrane transporter/Ion channel Potassium Channel KcsA 5-(4-Phenoxybutoxy)psoralen inhibit PAP1 Inhibitor PAP 1 inhibitor