Powder: -20°C for 3 years
In solvent: -80°C for 6 months
PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | 57.00 | |
5 mg | In stock | 81.00 | |
10 mg | In stock | 138.00 | |
25 mg | In stock | 307.00 | |
50 mg | In stock | 547.00 | |
100 mg | In stock | 918.00 | |
200 mg | In stock | 1378.00 | |
1 mL * 10 mM (in DMSO) | In stock | 92.00 |
Description | PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM). |
In vitro | PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50: 45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels [1, 2]. PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells (IC50: 10 nM) [1]. |
In vivo | PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats [1]. |
Cell Research |
Cell Line: CCR7-TEM cells (anti-CD3 Ab stimulated)
Concentration: 2, 10, 25, 100 nM
Incubation Time: 30 minutes [1]
|
Animal Research |
Animal Model: 9- to 11- week-old female Lewis rats
Dosage: I.P.; three times daily for 48 hours
Administration: 0.3, 1, 3 mg/kg [1]
|
Synonyms | 5-(4-Phenoxybutoxy)psoralen |
Purity | 99.49% |
Molecular Weight | 350.36 |
Formula | C21H18O5 |
CAS No. | 870653-45-5 |
Powder: -20°C for 3 years
In solvent: -80°C for 6 months
DMSO: 48 mg/mL (137 mM), Need ultrasonic
Water: Insoluble
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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