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Catalog No. T6956Cas No. 24305-27-9
Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
5 mg$47In Stock
10 mg$65In Stock
25 mg$135In Stock
50 mg$217In Stock
1 mL x 10 mM (in DMSO)$50In Stock
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Product Introduction

Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
In vivo
Protirelin (TRH), a neuropeptide predating the split between protostomes and deuterostomes, has likely played a role in regulating postembryonic growth and reproduction from its evolutionary origins. This study explores Protirelin's impact on body temperature, specifically through the administration of 1, 5, 10, and 20 mg/kg doses intraperitoneally to male Wistar rats (200-250 g). The findings reveal that Protirelin induces a temporary, dose-dependent increase in body temperature. Notably, thyroidectomized rats receiving a 20 mg/kg dose of Protirelin do not exhibit the significant hyperthermia observed in sham-operated counterparts, indicating that thyroid hormone release may be essential to Protirelin's hyperthermic effect.
Animal Research
Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.
AliasLopremone, pGlu-His-Pro-NH2, Synthetic thyrotropin-releasing hormone, Thyroliberin, TRH, TRF
Chemical Properties
Molecular Weight362.38
Cas No.24305-27-9
Storage & Solubility Information
Storagekeep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
Ethanol: 67 mg/mL (184.9 mM)
DMSO: 67 mg/mL (184.9 mM)
H2O: 66 mg/mL (182.1 mM)
Solution Preparation Table
1 mM2.7595 mL13.7977 mL27.5953 mL137.9767 mL
5 mM0.5519 mL2.7595 mL5.5191 mL27.5953 mL
10 mM0.2760 mL1.3798 mL2.7595 mL13.7977 mL
20 mM0.1380 mL0.6899 mL1.3798 mL6.8988 mL
50 mM0.0552 mL0.2760 mL0.5519 mL2.7595 mL
100 mM0.0276 mL0.1380 mL0.2760 mL1.3798 mL


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