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Prednisone

Catalog No. T1018   CAS 53-03-2
Synonyms: Dehydrocortisone

Prednisone (Dehydrocortisone) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

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Prednisone Chemical Structure
Prednisone, CAS 53-03-2
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Purity: 99.69%
Purity: 98.38%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Prednisone (Dehydrocortisone) is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
In vitro Prednisone blocks Peripheral blood lymphocytes (PBL) growth in the G1 phase of cell cycle and inhibits both IL-2 receptor (IL-2R) expression and IL-2 secretion in activated human peripheral blood T lymphocytes. Prednisone increases apoptosis in PHA-activated human PBL, and the apoptotic effect of Prednisone is stronger on CD8(+) than on CD4(+) T lymphocytes. [1]
In vivo Prednisone-treated rats show a significant delay of 20% in learning and memory retention in rats as compared with controls. [2] Prednisone results in reduced weight gain, unchanged alter uterine weight, lowered serum magnesium (Mg), unchange serum calcium (Ca), phosphate (P), 25-hydroxyvitamin D (25OHD), or 1,25-dihydroxyvitamin D [1,25(OH)2D], striking increased in calcified cartilage, reduced cross-sectional area and cortical area, unchange medullary area of the tibial diaphysis, lowered periosteal and endocortical bone formation and apposition rates, increased mean cancellous bone area and cancellous bone perimeter of the tibial metaphysis in both sham-operated and ovariectomized rats. [3] Prednisone-treated rabbit shows a 30% reduction in percent stenosis, a 35% decrease in neointimal area, and a 66% decrement in neointimal thickness. [4] Prednisone treatment significantly reduces the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but results in a higher level of the HP cross-link compared with untreated mdx mice. [5]
Synonyms Dehydrocortisone
Molecular Weight 358.43
Formula C21H26O5
CAS No. 53-03-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: <1 mg/mL

DMSO: 66 mg/mL (184.1 mM)

TargetMolReferences and Literature

1. Lanza L, et al. Clin Exp Immunol, 1996, 103(3), 482-490. 2. Ramos-Remus C, et al. J Investig Med, 2002, 50(6), 458-464. 3. Turner RT, et al. Calcif Tissue Int, 1995, 56(4), 311-315. 4. Ribichini F, et al. J Am Coll Cardiol, 2007, 50(2), 176-185. 5. Hartel JV, et al. Muscle Nerve, 2001, 24(3), 428-432.

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Keywords

Prednisone 53-03-2 Apoptosis Endocrinology/Hormones Immunology/Inflammation Glucocorticoid Receptor MRP inhibit Dehydrocortisone Inhibitor inhibitor

 

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