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Immunology/Inflammation MRP Prednisone

Prednisone

Catalog No. T1018   CAS 53-03-2
Synonyms: Dehydrocortisone

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.

Prednisone, CAS 53-03-2
Pack Size Availability Price/USD Quantity
25 mg In stock 22.00
50 mg In stock 30.00
100 mg In stock 38.00
500 mg In stock 50.00
1 g Inquiry 65.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.
Targets&IC50 Glucocorticoid Receptor,   MRP1,  
In vitro Prednisone blocks Peripheral blood lymphocytes (PBL) growth in the G1 phase of cell cycle and inhibits both IL-2 receptor (IL-2R) expression and IL-2 secretion in activated human peripheral blood T lymphocytes. Prednisone increases apoptosis in PHA-activated human PBL, and the apoptotic effect of Prednisone is stronger on CD8(+) than on CD4(+) T lymphocytes. [1]
In vivo Prednisone-treated rats show a significant delay of 20% in learning and memory retention in rats as compared with controls. [2] Prednisone results in reduced weight gain, unchanged alter uterine weight, lowered serum magnesium (Mg), unchange serum calcium (Ca), phosphate (P), 25-hydroxyvitamin D (25OHD), or 1,25-dihydroxyvitamin D [1,25(OH)2D], striking increased in calcified cartilage, reduced cross-sectional area and cortical area, unchange medullary area of the tibial diaphysis, lowered periosteal and endocortical bone formation and apposition rates, increased mean cancellous bone area and cancellous bone perimeter of the tibial metaphysis in both sham-operated and ovariectomized rats. [3] Prednisone-treated rabbit shows a 30% reduction in percent stenosis, a 35% decrease in neointimal area, and a 66% decrement in neointimal thickness. [4] Prednisone treatment significantly reduces the level of TGF-beta1 and HYP in diaphragm from mdx mice to values similar to control mice, but results in a higher level of the HP cross-link compared with untreated mdx mice. [5]
Synonyms Dehydrocortisone
Purity 98.38%
Molecular Weight 358.43
Formula C21H26O5
CAS No. 53-03-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 66 mg/mL (184.1 mM)

Ethanol: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Lanza L, et al. Clin Exp Immunol, 1996, 103(3), 482-490. 2. Ramos-Remus C, et al. J Investig Med, 2002, 50(6), 458-464. 3. Turner RT, et al. Calcif Tissue Int, 1995, 56(4), 311-315. 4. Ribichini F, et al. J Am Coll Cardiol, 2007, 50(2), 176-185. 5. Hartel JV, et al. Muscle Nerve, 2001, 24(3), 428-432.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Neuronal Signaling Compound Library Endocrinology-Hormones Library Hematopoietic Toxicity Compound Library FDA-approved Drug Library Immunology/Inflammation Compound Library GPCR Compound Library Cardiotoxicity Compound Library Anti-Metabolism Disease Compound Library Killers Collection CNS-Penetrant Compound Library

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