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Piperlonguminine

Catalog No. TN2085 CAS 5950-12-9

Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.Piperlonguminine is an inhibitor of Akt/mTOR signalling. It acts by promoting autophagy and mediating cancer cell death.

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Piperlonguminine, CAS 5950-12-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 52.00
5 mg	In stock	$ 123.00
10 mg	In stock	$ 197.00
25 mg	In stock	$ 332.00
50 mg	In stock	$ 496.00
100 mg	In stock	$ 693.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 99.91%

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Description	Piperlonguminine is an alkaloid amide isolated from the Piper species. Piperlonguminine shows anti-inflammatory, antitumor, neuroprotective, anti-platelet, anti-melanogenic, antifungal and antibacterial activities.Piperlonguminine is an inhibitor of Akt/mTOR signalling. It acts by promoting autophagy and mediating cancer cell death.
In vitro	Piperlonguminine from Piper longum was discovered to inhibit melanin production in melanoma B16 cells stimulated with alpha-melanocyte stimulating hormone (alpha-MSH), 3-isobutyl-1-methylxanthine or protoporphyrin IX, where the compound exhibited stronger depigmenting efficacy than kojic acid.?However, piperlonguminine did not affect 1-oleoyl-2-acetyl-sn-glycerol-induced melanogenesis and did not affect protein kinase C-mediated melanin production.?Surprisingly, piperlonguminine did not inhibit the catalytic activity of cell-free tyrosinase from melanoma B16 cells but rather suppressed tyrosinase mRNA expression.?This effect was attributed to the inhibitory action of piperlonguminine on alpha-MSH-induced signaling through cAMP to the cAMP responsive element binding protein that in turn regulates the expression of the microphthalmia-associated transcription factor, a key activator of the tyrosinase promoter.?This study demonstrates that piperlonguminine is an efficient depigmenting agent with a novel mechanism of action.
Source	Natural Products > Piperaceae > Piper

Molecular Weight	273.33
Formula	C16H19NO3
CAS No.	5950-12-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (100.61 mM), Sonication is recommended.

References and Literature

1. Inhibitory effect of piperlonguminine on melanin production in melanoma B16 cell line by downregulation of tyrosinase expression.Pigment Cell Res. 2006 Feb;19(1):90-8.

Related compound libraries

This product is contained In the following compound libraries：

Traditional Chinese Medicine Monomer Library Anti-Cancer Active Compound Library Inhibitor Library Natural Product Library Covalent Inhibitor Library RO5 Drug-like Natural Product Library Covalent Natural Product Library Anti-Tumor Natural Product Library Natural Product Library for HTS Antibiotics Library

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Keywords

Piperlonguminine 5950-12-9 Microbiology/Virology Antifungal Antibacterial Anti-infection amide Inhibitor inhibit alkaloid anti-melanogenic Bacterial antibacterial neuroprotective antifungal anti-platelet Fungal antitumor anti-inflammatory Piper inhibitor

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