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Pioglitazone

Catalog No. T0214 CAS 111025-46-8

Synonyms: U 72107

Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.

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Pioglitazone, CAS 111025-46-8

Pack Size	Availability	Price/USD
5 mg	In stock	$ 35.00
10 mg	In stock	$ 48.00
25 mg	In stock	$ 63.00
50 mg	In stock	$ 98.00
100 mg	In stock	$ 143.00
500 mg	In stock	$ 352.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.57%

Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.
Targets&IC50	PPARγ (human):0.93 μM (EC50), PPARγ (mouse):0.99 μM (EC50)
In vitro	In mouse models of Parkinson's disease (PD) using MPTP, Pioglitazone reduces activation of microglia, inducible nitric oxide synthase (iNOS) positive cells, and glial fibrillary acidic protein (GFAP) positive cells in the striatum and substantia nigra pars compacta. Administering approximately 20 mg/kg of Pioglitazone daily attenuates MPTP-induced neuroglial activation and prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Additionally, in 10-month-old APPV717I transgenic mice, Pioglitazone decreases the number of activated microglia and reactive astrocytes in the hippocampus and cortex. Pioglitazone also reduces mRNA and protein levels of beta-secretase-1 (BACE1), as well as the levels of soluble Abeta1-42 peptide.
In vivo	Pioglitazone is primarily metabolized by CYP2C8, with secondary metabolism by CYP3A4.

Synonyms	U 72107
Molecular Weight	356.44
Formula	C19H20N2O3S
CAS No.	111025-46-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 15 mg/mL (42.08 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

References and Literature

1. Jaakkola T, et al. Basic Clin Pharmacol Toxicol,2006, 99(1), 44-51. 2. Shiomi T, et al. Circulation,2002, 106(24), 3126-3132. 3. Dehmer T, et al. J Neurochem,2004, 88(2), 494-501. 4. Breidert T, et al. J Neurochem,2002, 82(3), 615-624. 5. Heneka MT, et al. Brain,2005, 128(Pt 6), 1442-1453. 6. Fang J, Zhang P, Wang Q, et al. Network-based Translation of GWAS Findings to Pathobiology and Drug Repurposing for Alzheimer's Disease[J]. medRxiv. 2020, 12(2): 025032.

Citations

1. Zhan Z T, Liu L, Cheng M Z, et al. The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment. Journal of Immunology Research. 2022 2. Qi Y, Hu M, Qiu Y, et al.Mitoglitazone ameliorates renal ischemia/reperfusion injury by inhibiting ferroptosis via targeting mitoNEET.Toxicology and Applied Pharmacology.2023: 116440. 3. Schöckel L, Woischke C, Surendran S A, et al.PPARG activation promotes the proliferation of colorectal cancer cell lines and enhances the antiproliferative effect of 5-fluorouracil.BMC cancer.2024, 24(1): 1-12. 4. Huang Q, Ru Y, Luo Y, et al.Identification of a targeted ACSL4 inhibitor to treat ferroptosis-related diseases.Science Advances.2024, 10(13): eadk1200.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library EMA Approved Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Bioactive Compounds Library Max Anti-Hypertension Compound Library ReFRAME Related Library Stem Cell Differentiation Compound Library

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Keywords

Pioglitazone 111025-46-8 Apoptosis DNA Damage/DNA Repair Metabolism PPAR Ferroptosis U 72107 Peroxisome proliferator-activated receptors diabete domain PPARγ inhibit U72107 blood glucose ligand-binding Inhibitor U-72107 inhibitor

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