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Metabolism PPAR Pioglitazone

Pioglitazone

Catalog No. T0214   CAS 111025-46-8
Synonyms: U 72107

Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.

Pioglitazone, CAS 111025-46-8
Pack Size Availability Price/USD Quantity
10 mg In stock 60.00
25 mg In stock 71.00
50 mg In stock 110.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 99.56%
Purity 98.18%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.
Targets&IC50 PPAR
Synonyms U 72107
Purity 99.56%
Molecular Weight 356.44
Formula C19H20N2O3S
CAS No. 111025-46-8

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 15 mg/mL (42.08 mM)

Ethanol: <1 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Jaakkola T, et al. Basic Clin Pharmacol Toxicol,2006, 99(1), 44-51. 2. Shiomi T, et al. Circulation,2002, 106(24), 3126-3132. 3. Dehmer T, et al. J Neurochem,2004, 88(2), 494-501. 4. Breidert T, et al. J Neurochem,2002, 82(3), 615-624. 5. Heneka MT, et al. Brain,2005, 128(Pt 6), 1442-1453. 6. Fang J, Zhang P, Wang Q, et al. Network-based Translation of GWAS Findings to Pathobiology and Drug Repurposing for Alzheimer's Disease[J]. medRxiv. 2020, 12(2): 025032.

Related compound libraries

This product is contained In the following compound libraries:
Approved Drug Library Bioactive Compound Library Inhibitor Library Anti-cancer Compound Library Clinical Compound Library Anti-diabetic Compound Library Stem cell Differentiation Compound Library Apoptosis Compound Library FDA-approved Drug Library Immunology/Inflammation Compound Library DNA Damage & Repair Compound Library Anti-cancer Approved drug Library Anti-cancer Clinical Compound Library Cardiotoxicity Compound Library Anti-Metabolism Disease Compound Library Anti-cancer Metabolism Compound Library Nuclear-receptor Inhibitors Library Anti-obesity Compound Library Anti-aging Compound Library Anti-cancer Drug library Drug Repurposing Library Ferroptosis Compound Library Neurodegenerative disease-related Compound Library Drug-induced Liver Injury (DILI) Compound Library NMPA-Approved Drug Library FDA Approved & Pharmacopeial Drug Library Lipid Metabolism Compound Library Glycometabolism Compound Library Anti-Alzheimer's Disease Compound Library

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Related compounds with same targets
INT-131 12-O-Methylcarnosic acid Oleoylethanolamide GW1929 GW 6471 3-Guanidinopropionic Acid Growth hormone releasing peptide Ailanthoidol

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.