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Pioglitazone

Catalog No. T0214 CAS 111025-46-8

Synonyms: 匹格列酮, U 72107, 吡格列酮

Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.

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Pioglitazone, CAS 111025-46-8

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes. Pioglitazone has been linked to rare instances of acute liver injury.
Targets&IC50	human PPARγ:0.93 μM (EC50), mouse PPARγ:0.99 μM (EC50)

Synonyms	匹格列酮, U 72107, 吡格列酮
Molecular Weight	356.44
Formula	C19H20N2O3S
CAS No.	111025-46-8

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 15 mg/mL (42.08 mM)

Ethanol: <1 mg/mL

H2O: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Jaakkola T, et al. Basic Clin Pharmacol Toxicol,2006, 99(1), 44-51. 2. Shiomi T, et al. Circulation,2002, 106(24), 3126-3132. 3. Dehmer T, et al. J Neurochem,2004, 88(2), 494-501. 4. Breidert T, et al. J Neurochem,2002, 82(3), 615-624. 5. Heneka MT, et al. Brain,2005, 128(Pt 6), 1442-1453. 6. Fang J, Zhang P, Wang Q, et al. Network-based Translation of GWAS Findings to Pathobiology and Drug Repurposing for Alzheimer's Disease[J]. medRxiv. 2020, 12(2): 025032.

Citations

1. Zhan Z T, Liu L, Cheng M Z, et al. The Effects of 6 Common Antidiabetic Drugs on Anti-PD1 Immune Checkpoint Inhibitor in Tumor Treatment. Journal of Immunology Research. 2022

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Lipid Metabolism Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library Anti-Metabolism Disease Compound Library

Related Products

Related compounds with same targets

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pioglitazone 111025-46-8 DNA损伤和修复代谢凋亡细胞周期 Ferroptosis PPAR Peroxisome proliferator-activated receptors diabete domain PPARγ inhibit U 72107 U-72107 blood glucose ligand-binding Inhibitor U72107 inhibitor

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