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Pifithrin-α, p-Nitro, Cyclic

Catalog No. T12472 CAS 60477-38-5

Synonyms: PFN-α

Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.

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Pifithrin-α, p-Nitro, Cyclic Chemical Structure

Pifithrin-α, p-Nitro, Cyclic, CAS 60477-38-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 263.00
50 mg	In stock	$ 428.00
100 mg	In stock	$ 639.00
1 mL * 10 mM (in DMSO)	In stock	$ 79.00

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Purity: 99.97%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pifithrin-α, p-Nitro, Cyclic (PFN-α) (PFN-α) is cell-permeable and active-form inhibitor of p53.
In vitro	Pifithrin-α, p-Nitro, Cyclic (PFN-α) effectively inhibits p53-induced cell death and p21/WAF1 expression in cortical neurons when exposed to etoposide, requiring concentrations an order of magnitude lower compared to PFT-α[1].
In vivo	Intraocular administration of pifithrin-α at a concentration of 6 µM modestly enhances the survival of retinal ganglion cells (RGC), while it remains ineffective at 0.06 µM. Despite the observed in vitro benefits, pifithrin-α, p-Nitro, Cyclic (PFN-α) demonstrates no in vivo efficacy, even at the 6 µM concentration. Furthermore, pifithrin-α, p-Nitro, Cyclic exhibits a half-life (t1/2) of 6 hours under biological conditions[1].

Synonyms	PFN-α
Molecular Weight	299.35
Formula	C15H13N3O2S
CAS No.	60477-38-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5 mg/mL (16.70 mM), Sonification is recommended.

DMF: 12.5 mg/mL (41.76 mM), Sonification is recommended.

References and Literature

1. Pietrancosta N, et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J Med Chem. 2006 Jun 15;49(12):3645-52. 2. Dinca EB, et al. p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer Res. 2008 Dec 15;68(24):10034-9.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Compound Library PPI Inhibitor Library Bioactive Compounds Library Max Transcription Factor-Targeted Compound Library Ferroptosis Compound Library Pyroptosis Compound Library Anti-Lung Cancer Compound Library Anti-Aging Compound Library

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Keywords

Pifithrin-α, p-Nitro, Cyclic 60477-38-5 Apoptosis p53 MDM-2/p53 PFN-α Inhibitor expression p21 neurons cortical Pifithrin-a, p-Nitro, Cyclic WAF1 Pifithrinα, pNitro, Cyclic inhibit death p53-triggered PFN-alpha posttranscriptional cell Pifithrin-alpha, p-Nitro, Cyclic Pifithrin α, p Nitro, Cyclic PFN-a inhibitor

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