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Pentostatin

Catalog No. T4006 CAS 53910-25-1

Synonyms: 喷司他丁, Covidarabine, CI-825, Deoxycoformycin, Nipent

Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).

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Pentostatin, CAS 53910-25-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Pentostatin is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
Targets&IC50	adenosine deaminase:2.5 pM (Ki)

Synonyms	喷司他丁, Covidarabine, CI-825, Deoxycoformycin, Nipent
Molecular Weight	268.273
Formula	C11H16N4O4
CAS No.	53910-25-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 50 mg/mL (186.38 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Nabhan, et Al. Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429. 2. Klohs Klohs WD., et al. Pentostatin: future directions. Pharmacol.Rev. 44 459. 3. Reynolds C., et al. Richards DA, Robbins GJ, Vellek M, Boehm KA, Zhan F, Asmar L.A Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia.Invest New Drugs. 2012 Jun;30(3):1232-40. Epub 2011 Sep 16. 4. Grever MR.Hairy cell leukemia: a successful model for experimental therapeutics--pentostatin and new ideas.Leuk Lymphoma. 2011 Jun;52 Suppl 2:25-8. 5. Dearden CE, Else M, Catovsky D.Long-term results for pentostatin and cladribine treatment of hairy cell leukemia.Leuk Lymphoma. 2011 Jun;52 Suppl 2:21-4. 6. Wang J, Liu Y, Liu Y, et al. Time-resolved protein activation by proximal decaging in living systems[J]. Nature. 2019 May;569(7757):509-513.

Citations

1. Wang J, Liu Y, Liu Y, et al. Time-resolved protein activation by proximal decaging in living systems. Nature. 2019, 569(7757): 509-513.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library GPCR Compound Library Neurotransmitter Receptor Compound Library Hematonosis Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Nucleotide Compound Library DNA Damage & Repair Compound Library Anti-Metabolism Disease Compound Library Covalent Inhibitor Library

Related Products

Related compounds with same targets

Hibifolin 8-Azaadenosine Pentostatin Cladribine Erdosteine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pentostatin 53910-25-1 G蛋白偶联受体代谢神经科学 Adenosine deaminase Adenosine Receptor Nipent Deoxycoformycin CI 825 Covidarabine Adenosine Deaminase Inhibitor inhibit CI-825 CI825 inhibitor

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