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Pentostatin

Catalog No. T4006   CAS 53910-25-1
Synonyms: Nipent, CI-825, Covidarabine, Deoxycoformycin

Pentostatin (CI-825) is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).

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Pentostatin Chemical Structure
Pentostatin, CAS 53910-25-1
Pack Size Availability Price/USD Quantity
2 mg In stock $ 37.00
5 mg In stock $ 48.00
10 mg In stock $ 80.00
25 mg In stock $ 193.00
50 mg In stock $ 360.00
100 mg In stock $ 535.00
1 mL * 10 mM (in DMSO) In stock $ 65.00
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Purity: 99.89%
Purity: 99.66%
Purity: 99.47%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Pentostatin (CI-825) is an extremely effective and irreversible inhibitor of adenosine deaminase (Ki: 2.5 pM).
Targets&IC50 Adenosine deaminase:2.5 pM (Ki)
Synonyms Nipent, CI-825, Covidarabine, Deoxycoformycin
Molecular Weight 268.27
Formula C11H16N4O4
CAS No. 53910-25-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (186.38 mM)

TargetMolReferences and Literature

1. Nabhan, et Al. Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era. Leukemia Res. 28 429. 2. Klohs Klohs WD., et al. Pentostatin: future directions. Pharmacol.Rev. 44 459. 3. Reynolds C., et al. Richards DA, Robbins GJ, Vellek M, Boehm KA, Zhan F, Asmar L.A Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia.Invest New Drugs. 2012 Jun;30(3):1232-40. Epub 2011 Sep 16. 4. Grever MR.Hairy cell leukemia: a successful model for experimental therapeutics--pentostatin and new ideas.Leuk Lymphoma. 2011 Jun;52 Suppl 2:25-8. 5. Dearden CE, Else M, Catovsky D.Long-term results for pentostatin and cladribine treatment of hairy cell leukemia.Leuk Lymphoma. 2011 Jun;52 Suppl 2:21-4. 6. Wang J, Liu Y, Liu Y, et al. Time-resolved protein activation by proximal decaging in living systems[J]. Nature. 2019 May;569(7757):509-513.

TargetMolCitations

1. Wang J, Liu Y, Liu Y, et al. Time-resolved protein activation by proximal decaging in living systems. Nature. 2019, 569(7757): 509-513.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Inhibitor Library Anti-Cancer Active Compound Library Anti-Cancer Approved Drug Library Anti-Cancer Drug Library GPCR Compound Library Membrane Protein-targeted Compound Library Neuronal Signaling Compound Library Covalent Inhibitor Library

Related Products

Related compounds with same targets
8-Azaadenosine 3’-O-Methyladenosine Cladribine Erdosteine Hibifolin

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pentostatin 53910-25-1 GPCR/G Protein Metabolism Neuroscience Adenosine deaminase Adenosine Receptor CI825 Nipent CI-825 Covidarabine CI 825 Adenosine Deaminase Inhibitor Deoxycoformycin inhibit inhibitor

 

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