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Pentiapine

Catalog No. T12405 CAS 81382-51-6

Synonyms: CGS 10746

Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.

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Pentiapine, CAS 81382-51-6

Pack Size	Availability	Price/USD
1 mg	In stock	$ 623.00
5 mg	In stock	$ 995.00
10 mg	In stock	$ 1,590.00
25 mg	In stock	$ 2,350.00
50 mg	In stock	$ 3,180.00
100 mg	In stock	$ 4,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 987.00

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Purity: 98.93%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.

In vivo

Pentiapine effectively reduces motor activity in mice, both independently and in diminishing morphine-induced hyperactivity, on a dose-dependent basis. Analysis through Newman-Keuls post-hoc comparisons reveals that mice administered morphine and saline exhibit higher activity levels compared to those treated with incremental doses of 2 to 32 mg/kg of Pentiapine, with significant activity reductions observed at the 2 (P<0.05) and 32 (P<0.01) mg/kg levels. Additionally, lower doses of Pentiapine (0.5, 1, and 2 mg/kg) result in more activity than higher doses (4 to 32 mg/kg) in morphine-treated groups (P<0.01)[1]. A 30 mg/kg dose of Pentiapine completely inhibits the conditioned place preference (CPP) induced by methylenedioxymethamphetamine (MDMA) and prevents the establishment of a cocaine-induced CPP[2], demonstrating its potential in mitigating addictive behaviors.

Synonyms	CGS 10746
Molecular Weight	299.39
Formula	C15H17N5S
CAS No.	81382-51-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95 mg/mL (317.31 mM), Sonication is recommended.

References and Literature

1. Manzanedo C, et al. Effects of CGS 10746B on hyperactivity and place preference induced by morphine. Behav Brain Res. 2001 Nov 29;126(1-2):23-32. 2. Bilsky EJ, et al. CGS 10746B, a novel dopamine release inhibitor, blocks the establishment of cocaine and MDMA conditioned place preferences. Pharmacol Biochem Behav. 1998 Jan;59(1):215-20.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library GPCR Compound Library Anti-Neurodegenerative Disease Compound Library Membrane Protein-targeted Compound Library ReFRAME Related Library Neuronal Signaling Compound Library Neurotransmitter Receptor Compound Library Bioactive Compounds Library Max Bioactive Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Pentiapine 81382-51-6 GPCR/G Protein Neuroscience Dopamine Receptor inhibit Inhibitor CGS 10746 CGS-10746 CGS10746 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.