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Omeprazole

Omeprazole
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Purity:97.61%
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Omeprazole

Catalog No. T0757Cas No. 73590-58-6
Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
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Pack SizePriceAvailabilityQuantity
50 mg$40In Stock
100 mg$48In Stock
200 mg$63In Stock
500 mg$97In Stock
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Product Introduction

Bioactivity
Description
Omeprazole (Losec) is a proton pump inhibitor (PPI), Omeprazole(Losec) is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor).
In vitro
Omeprazole transiently alters the kinetic properties of parietal cells in rabbits, leading to premature cell death and expedited growth. By inhibiting H(+)-K(+)-ATPase, omeprazole enhances the clearance of degenerative changes and macrophage-mediated removal of parietal cells, as well as promoting the increase of progenitor cells at the apical ridge.
In vivo
Omeprazole diminishes the activation of osteoclasts in vitro, while enhancing the activation of osteoblasts, leading to osteosclerosis-like effects to some extent. In human hepatocellular carcinoma cells, omeprazole induces the transcription of reporter genes through dioxin receptor elements recognized by ligand-activated aryl hydrocarbon receptors. It effectively induces the expression of cytochrome P4501A1 mRNA in primary human hepatocytes, but this induction is not detected in mouse primary hepatocytes. Omeprazole significantly suppresses the basal natural killer (NK) activity in splenocytes (SC) from untreated CD2F1 mice. It exerts rapid and robust effects on various types of cytotoxic lymphocytes, ranging from the inhibition of cytotoxicity to irreversible cellular damage. Furthermore, omeprazole notably inhibits the cytotoxicity of all types of effector cells after 30 minutes of incubation.
AliasLosec, Prilosec, H 16868, Antra
Chemical Properties
Molecular Weight345.42
FormulaC17H19N3O3S
Cas No.73590-58-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
1eq. HCl: 17.3 mg/mL (50 mM)
Ethanol: 20 mg/ml (57.90 mM), Sonication is recommended.
DMSO: 100 mg/ml (289.50 mM), Sonication is recommended.
Solution Preparation Table
DMSO/1eq. HCl
1mg5mg10mg50mg
1 mM2.8950 mL14.4751 mL28.9503 mL144.7513 mL
5 mM0.5790 mL2.8950 mL5.7901 mL28.9503 mL
10 mM0.2895 mL1.4475 mL2.8950 mL14.4751 mL
20 mM0.1448 mL0.7238 mL1.4475 mL7.2376 mL
DMSO
1mg5mg10mg50mg
50 mM0.0579 mL0.2895 mL0.5790 mL2.8950 mL
100 mM0.0290 mL0.1448 mL0.2895 mL1.4475 mL

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