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OXOMEMAZINE

Catalog No. T9353 CAS 3689-50-7

Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low (Ki=1.65 μM, M2 receptors) affinity sites 20 times the difference[1]. Oxomemazine is an antihistamine and anticholinergic agent used in studies related to cough studies[2].

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OXOMEMAZINE, CAS 3689-50-7

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10 mg	In stock	$ 48.00

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Purity: 99.49%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Oxomemazine is a phenothiazine-based histamine H1-receptor blocker with pronounced antimuscarinic activity. Oxomemazine is a selective antagonist of mycotoxins M1 receptors, showing high (Ki=84 nM, M1 receptors) and low (Ki=1.65 μM, M2 receptors) affinity sites 20 times the difference[1]. Oxomemazine is an antihistamine and anticholinergic agent used in studies related to cough studies[2].
Targets&IC50	mGluR1:84 nM (Ki), mGluR2:1.65 μM (Ki)

Molecular Weight	330.44
Formula	C18H22N2O2S
CAS No.	3689-50-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 10mg/mL (30.26mM)

DMSO: 30mg/mL (90.79mM)

References and Literature

1. S W Lee, et al.Selectivity of oxomemazine for the M1 muscarinic receptors.Arch Pharm Res. 1994 Dec;17(6):443-51. 2. M S Siddegowda, et al.Oxomemazine hydro-chloride. Acta Crystallogr Sect E Struct Rep Online. 2011 Aug 1;67(Pt 8):o1875.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library GPCR Compound Library Drug Repurposing Compound Library Neurotransmitter Receptor Compound Library Bioactive Compound Library Anti-Alzheimer's Disease Compound Library Neuronal Signaling Compound Library

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Related compounds with same targets

Cytisinicline Donepezil Hydrochloride TC-2216 Methyllycaconitine citrate Dehydrodicentrine SIB-1553A hydrochloride PQCA Doxepin hydrochloride

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

OXOMEMAZINE 3689-50-7 GPCR/G Protein Immunology/Inflammation Neuroscience AChR Histamine Receptor histamine H1-receptor inhibit phenothiazine antimuscarinic muscarinic M1 Inhibitor Metabotropic glutamate receptors cough anticholinergic antihistamine mGluR inhibitor

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