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ONO-5334

Catalog No. T16394 CAS 868273-90-9

ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 has the potential for the study of osteoporosis.

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ONO-5334, CAS 868273-90-9

Pack Size	Availability	Price/USD
25 mg	10-14 weeks	$ 1,220.00
50 mg	10-14 weeks	$ 1,590.00
100 mg	10-14 weeks	$ 2,420.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	ONO-5334 is an effective and selective cathepsin K inhibitor (Ki: 0.10 nM, 0.049 nM, and 0.85 nM for human, rabbit, and rat cathepsin K, respectively). ONO-5334 has the potential for the study of osteoporosis.
Targets&IC50	Cathepsin K (rabbit):（ki）0.049 nM, Cathepsin K (rat):（ki）0.85 nM, Cathepsin K (human):（ki）0.10 nM
In vitro	ONO-5334 has inhibitory effects on human cathepsin S, human cathepsin L, human cathepsin B, porcine calpain Ι and porcine calpain II (Ki: 0.83 nM, 1.7 nM, 32 nM, 82 nM, and 69 nM, respectively). ONO-5334 (0.1-1 μM; 24 hours) inhibits human osteoclast-mediated bone resorption. It effectively decreases the osteoclast-mediated release of CTX from bone slices as a dose-dependent manner[1].
In vivo	ONO-5334 (p.o.; 0.3-30 mg/kg; 7 consecutive days) at 3 mg/kg or 30 mg/kg obviously reduces CTX (a bone resorption marker) concentration. ONO-5334 (p.o.; 0.12-15 mg/kg; single dose) can dose-dependently decrease PTHrP-induced increase in plasma calcium with significant effect (86% reduction) at 15 mg/kg. It also decreases PTHrP-induced increase in plasma CTX level in TPTX rats by 90% at 15 mg/kg. On day 7, the reduction in serum CTX concentration by ONO-5334 at 3 mg/kg and 30 mg/kg was 62% and 79%, respectively[1].

Molecular Weight	438.58
Formula	C21H34N4O4S
CAS No.	868273-90-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Ochi Y, et al. Effects of ONO-5334, a novel orally-active inhibitor of cathepsin K, on bone metabolism. Bone. 2011 Dec;49(6):1351-6.

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Keywords

ONO-5334 868273-90-9 Proteases/Proteasome Cysteine Protease ONO 5334 ONO5334 inhibitor inhibit

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