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Nabumetone

Catalog No. T1258   CAS 42924-53-8
Synonyms: BRL14777

Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.

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Nabumetone Chemical Structure
Nabumetone, CAS 42924-53-8
Pack Size Availability Price/USD Quantity
500 mg In stock $ 45.00
1 g In stock $ 53.00
1 mL * 10 mM (in DMSO) In stock $ 50.00
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Purity: 99.61%
Purity: 98.91%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
Kinase Assay Cells are harvested, washed, and lysed in NP-40 lysis buffer (50 mM Tris-HCl [pH 7.5], 150 mM NaCl, 0.5% NP-40). Total cell protein is quantified using the Bradford assay and 1-mg/mL protein aliquots are made. Ten microliters of total cell protein is mixed with 290 μL of substrate solution (0.1 mg/mL dithiothreitol [DTT], 0.1 mg/mL albumin, and 1 mM alanine-β-naphthylamide). Fluorometric measurements (340 nm excitation, 400 nm emission) are made after 15 and 30 min. The slope of the line between the 15- and 30-min measurements is used to represent aminopeptidase activity. Total cell protein is preincubated with bestatin, amastatin, puromycin, EDTA, and/or ZnCl2 for 20 min before the fluorometric aminopeptidase assay.
Synonyms BRL14777
Molecular Weight 228.29
Formula C15H16O2
CAS No. 42924-53-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 43 mg/mL (188.4 mM)

Ethanol: 24 mg/mL (105.1 mM)

TargetMolReferences and Literature

1. Hedner T, et al. Drugs, 2004, 64(20), 2315-2343. 2. Boyle EA, et al. J Pharm Pharmacol, 1982, 34(9), 562-569.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Anti-Cancer Approved Drug Library Metabolism Compound Library Anti-Metabolism Disease Compound Library FDA-Approved & Pharmacopeia Drug Library Clinical Compound Library FDA-Approved Drug Library ReFRAME Related Library Bioactive Compounds Library Max

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Keywords

Nabumetone 42924-53-8 Immunology/Inflammation Metabolism Neuroscience Glutathione Peroxidase COX Cyclooxygenase Inhibitor BRL14777 inhibit BRL 14777 BRL-14777 inhibitor

 

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