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Lupanine
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Catalog No. TMA0805Cas No. 550-90-3
Alias D-Lupanine, (+)-Lupanine
Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.
Lupanine
😃Good
Catalog No. TMA0805Alias D-Lupanine, (+)-LupanineCas No. 550-90-3
Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,309 | 6-8 weeks | |
| 25 mg | Inquiry | 6-8 weeks | |
| 50 mg | Inquiry | 6-8 weeks | |
| 100 mg | Inquiry | 6-8 weeks |
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Product Introduction
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Chemical Properties
| Description | Lupanine ((+)-Lupanine), a naturally occurring quinolizidine alkaloid, potently affinity and activates nicotinic acetylcholine receptor (nAChR) (Ki=500 nM), and shows significant neuroprotection against soluble amyloid β-oligomers (SO-Aβ) toxicity in cellular models in association with the anti-apoptotic PI3K/ Akt/Bcl-2 signaling pathway with anti-Alzheimer's disease potential. Improves glucose homeostasis by affecting KATP channels and enhancing insulin secretion with therapeutic potential for type 2 diabetes. |
| In vitro | Lupanine (0-100 μM) treats SH-SY5Y cells with EC50 and DC50 values of 10.7 μM and 28.2 μM, respectively. [2] |
| In vivo | Methods: Lupanine (20 mg/kg, orally) was administered to non-diabetic and diabetic rats, and an oral glucose tolerance test was performed 30 minutes later. Results: Lupanine reduced blood glucose concentrations and improved glycemic control in an in vivo diabetic rat model. [3] |
| Synonyms | D-Lupanine, (+)-Lupanine |
| Molecular Weight | 248.36 |
| Formula | C15H24N2O |
| Cas No. | 550-90-3 |
| Smiles | O=C1N2[C@@]([C@]3(C[C@@](C2)([C@]4(N(C3)CCCC4)[H])[H])[H])(CCC1)[H] |
| Relative Density. | 1.16g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight | store at 4°C | Shipping with blue ice. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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