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NBQX Disodium

Catalog No. T25853 CAS 479347-86-9

Synonyms: FG9202 disodium, NBQX 2Na

NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity. NBQX Disodium is a salt of NBQX. NBQX is a potent and selective AMPA/rhodosinate receptor antagonist that can be used to antagonize the excitatory toxicity of glutamate. It has anticonvulsant effects in rodent models.

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NBQX Disodium, CAS 479347-86-9

Pack Size	Availability	Price/USD
1 mg	In stock	$ 62.00
5 mg	In stock	$ 117.00
10 mg	In stock	$ 145.00
25 mg	In stock	$ 329.00
50 mg	In stock	$ 488.00
100 mg	In stock	$ 713.00

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Purity: 98.22%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity. NBQX Disodium is a salt of NBQX. NBQX is a potent and selective AMPA/rhodosinate receptor antagonist that can be used to antagonize the excitatory toxicity of glutamate. It has anticonvulsant effects in rodent models.
Targets&IC50	AMPA:0.7 ± 0.1 μM, Kainic acid:0.7 ± 0.03 μM
In vitro	In HIP-009 cells, NBQX disodium salt inhibited both AMPA or kainic acid (KA) induced signals in a concentration-dependent manner, with IC50 values being 0.7 ± 0.1 and 0.7 ± 0.03 μM, respectively. The AMPA-evoked calcium rise was completely inhibited by NBQX disodium salt, whereas 68.6% ± 1.3% inhibition of the KA-induced signal was observed with 30 μM of NBQX disodium salt treatment.[1]
In vivo	Administration of NBQX disodium (FG9202; 20 mg/kg, i.p.; for 3 days) exhibits a reduction in PTZ-induced seizures. [2] In a rat model of focal ischemia, NBQX disodium demonstrates neuroprotective effects when administered intravenously as a bolus dose of 30 mg/kg at the time of MCA occlusion, followed by an additional dose at 1 hour post-occlusion. [3]

Synonyms	FG9202 disodium, NBQX 2Na
Molecular Weight	380.24
Formula	C12H6N4Na2O6S
CAS No.	479347-86-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 34.2 mg/mL(90.0 mM), Sonication is recommended.

References and Literature

1. Fukushima K, et al. Characterization of Human Hippocampal Neural Stem/Progenitor Cells and Their Application to Physiologically Relevant Assays for Multiple Ionotropic Glutamate Receptors. J Biomol Screen. 2014;19(8):1174-1184. 2. Chen W, et al. AMPA Receptor Antagonist NBQX Decreased Seizures by Normalization of Perineuronal Nets. PLoS One. 2016;11(11):e16667 3. T001 4. Twele F, et al. The AMPA receptor antagonist NBQX exerts anti-seizure but not antiepileptogenic effects in the intrahippocampal kainate mouse model of mesial temporal lobe epilepsy. Neuropharmacology. 2015;95:234-242. 5. Ruda-Kucerova J, et al. NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats. World J Biol Psychiatry. 2021;22(10):733-743.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Neurodegenerative Disease Compound Library Bioactive Compound Library Bioactive Compounds Library Max Neuronal Signaling Compound Library

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Keywords

NBQX Disodium 479347-86-9 Neuroscience GluR FG 9202 FG9202 disodium FG-9202 NBQX NBQX 2Na FG9202 inhibitor inhibit

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