Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1b
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
5 mg | In stock | $ 80.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 228.00 | |
50 mg | In stock | $ 372.00 | |
100 mg | In stock | $ 549.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 81.00 |
Description | CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1b |
Targets&IC50 | mGluR1b (human):6.5 μM |
In vitro | CPCCOEt selectively inhibited glutamate-induced increases in intracellular calcium at human mGluR1b (hmGluR1b) with an apparent IC50 of 6.5 μM while having no agonist or antagonist activity at hmGluR2, -4a, -5a, -7b, and -8a up to 100 μM. In addition, introduction of Thr815 and Ala818 at the homologous positions of hmGluR5a conferred complete inhibition by CPCCOEt (IC50 = 6.6 μM)[1]. |
In vivo | Whole-cell voltage recording from Purkinje cells in slices of rat cerebellum showed that CPCCOEt enhanced the climbing fiber response at concentrations of blocking the mGlu1 receptor(100 μM)[2]. |
Molecular Weight | 247.25 |
Formula | C13H13NO4 |
CAS No. | 179067-99-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (364.0 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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CPCCOEt 179067-99-3 Neuroscience GluR inhibitor inhibit