Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
20 mg | In stock | $ 50.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | Myricitrin (Myricitrine), a flavonoid compound isolated from the root bark of Myrica cerifera, exerts antinociceptive effects. |
In vitro | In mice, Myricitrin (10/30 mg/kg, i.p.) blocks apomorphine-induced stereotypy and climbing behaviors, while also prolonging the hindlimb withdrawal time. |
In vivo | In rodent models of chemical and mechanical pain, Flurbiprofen activates protein kinase Cα and PKCε, while Myricitrin blocks this action, thereby exerting a significant analgesic effect. The pain-relief mechanism of Myricitrin is attributed to a decrease in calcium ion influx and the opening of voltage-dependent and small-conductance calcium-activated potassium (K+) channels. Additionally, Myricitrin inhibits the expression of the p53 gene, which leads to the activation of caspase-3 and the MAPK signaling pathway, while altering the expression pattern of anti-apoptotic and pro-apoptotic genes. Consequently, this reduces H₂O₂-induced apoptosis in vascular endothelial cells. |
Source |
Synonyms | Myricetrin, Myricitrine |
Molecular Weight | 464.38 |
Formula | C21H20O12 |
CAS No. | 17912-87-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 86 mg/mL (185.2 mM)
Ethanol: 1 mg/mL (2.15 mM)
You can also refer to dose conversion for different animals. More
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Myricitrin 17912-87-7 Chromatin/Epigenetic Cytoskeletal Signaling PKC antioxidant Inhibitor inhibit Myricetrin Myricitrine inhibitor