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Stem Cells TGF-beta/Smad Monocrotaline

Monocrotaline

Catalog No. T2803   CAS 315-22-0
Synonyms: Crotaline

Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes is noted after oral magnesium treatment.

Monocrotaline, CAS 315-22-0
Pack Size Availability Price/USD Quantity
25 mg In stock 40.00
50 mg In stock 57.00
100 mg In stock 91.00
200 mg In stock 159.00
1 mL * 10 mM (in DMSO) In stock 59.00
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Purity 99.59%
Purity 98.00%
Purity 99.13%
Purity 99.51%
Purity 99.44%
Purity 99.46%
Purity 97.30%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Monocrotaline is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes is noted after oral magnesium treatment.
Targets&IC50 TGFβ
In vivo MCT causes a pulmonary vascular syndrome in rats characterized by proliferative pulmonary vasculitis, pulmonary hypertension (PH), and cor pulmonale[3]. Among preClinicalal models of pulmonary arterial hypertension (PAH), monocrotaline animal model offers the advantage of mimic several key aspects of human PAH, including vascular remodeling, proliferation of smooth muscle cells, endothelial dysfunction, upregulation of inflammatory cytokines, and right ventricle failure, requiring a single drug injection[4]. Changes in multiple pathways associated with the development of PH, including activated glycolysis, increased markers of proliferation, disruptions in carnitine homeostasis, increased inflammatory and fibrosis biomarkers, and a reduction in glutathione biosynthesis are observed with the injection of monocrotaline[5].
Synonyms Crotaline
Purity 99.59%
Molecular Weight 325.36
Formula C16H23NO6
CAS No. 315-22-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 25 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Gomez-Arroyo JG, et al. The monocrotaline model of pulmonary hypertension in perspective. Am J Physiol Lung Cell Mol Physiol. 2012 Feb 15;302(4):L363-9. 2. Kusuma SS, et al. Antineoplastic activity of monocrotaline against hepatocellular carcinoma. Anticancer Agents Med Chem. 2014;14(9):1237-48. 3. Wilson DW, et, al. Mechanisms and pathology of monocrotaline pulmonary toxicity. Crit Rev Toxicol. 1992;22(5-6):307-25. 4. Nogueira-Ferreira R, et al. Exploring the monocrotaline animal model for the study of pulmonary arterial hypertension: A network approach. Pulm Pharmacol Ther. 2015 Dec;35:8-16. 5. Rafikova O,et al. Metabolic Changes Precede the Development of Pulmonary Hypertension in the Monocrotaline Exposed RatLung. PLoS One. 2016 Mar 3;11(3):e20150480.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Inhibitor Library Natural Compound Library for HTS Anti-cancer Compound Library Clinical Compound Library Stem cell Differentiation Compound Library Selected Plant-sourced Compound Library Cytokine Inhibitor Library Anti-cancer Clinical Compound Library TGF-beta/Smad Compound Library Food as Medicine Library Anti-aging Compound Library Antitumor Natural Products Library Natural Compoud Library in Chinese Pharmacopoeia Anti-cancer Drug library Drug Repurposing Library Macrocyclic Compounds Library Target-Focused Phenotypic Screening Library Small Molecule Immuno-Oncology Compound Library Anti-Inflammatory Tradition Chinese Medicine Library Alkaloids natural compound library HIF-1 Signaling Pathway Compound Library Anti-Lung Cancer Compound Library Drug-induced Liver Injury (DILI) Compound Library Tibetan medicine Compound Library FDA Approved & Pharmacopeial Drug Library Traditional Chinese Medicine Monomer Library Anti-Breast Cancer Compound Library Anti-Pancreatic Cancer Compound Library Anti-fibrosis Compound Library

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