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Methoxsalen

Methoxsalen
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Purity:99.82%
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Methoxsalen

Catalog No. T1548Cas No. 298-81-7
Methoxsalen (NCI-C55903) is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.
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Pack SizePriceAvailabilityQuantity
50 mg$29In Stock
1 mL x 10 mM (in DMSO)$48In Stock
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Product Introduction

Bioactivity
Description
Methoxsalen (NCI-C55903) is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.
In vitro
Methoxsalen inhibits CYP2A6 (Ki = 0.8 μM) with about 3.5- 94-fold greater potency than other P450s, except for CYP1A2 (Ki = 0.2 μM). Methoxsalen shows noncompetitive inhibition of nicotine metabolism, with an apparent Ki value of 0.1 μM in cDNA-expressing microsomes. [1] Methoxsalen is metabolized in human liver microsomes at the rate of 50-100 pmol/mg protein/min (approx. 30% of the activity in mouse liver microsomes). Methoxsalen is a very potent inhibitor of human cytochrome P450 2A6 (CYP2A6) and mouse Cyp2a-5-mediated coumarin 7-hydroxylation in vitro. [2]
In vivo
Methoxsalen results in a significant decrease in the following factors: number and diameter of corpus lutei, Graafian follicles, diameter of granulosa cell layer and oocytes, number of primordial and primary and growing follicles, while the number of atretic follicle is increased. Methoxsalen also significantly reduces circulating estrogen levels in blood serum of oogenesis Balb/C mice. [3] Methoxsalen dose-dependently stimulates a sustained increase in short-circuit current in the mouse jejunum. Methoxsalen increases the open probability of the basolateral IK(Ca) channel of isolated crypts in the mouse jejunum. [4] Methoxsalen effectively reverses trimethyltin (TMT)-induced memory impairment on both Y-maze and passive avoidance tests in mice. Methoxsalen inhibits brain AchE activity. Methoxsalen significantly ameliorates the level of oxidative stress. [5]
AliasNCI-C55903, Xanthotoxin, 8-Methoxypsoralen, 8-MOP
Chemical Properties
Molecular Weight216.19
FormulaC12H8O4
Cas No.298-81-7
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 5 mg/mL (23.12 mM)
DMSO: 40 mg/mL (185 mM)
Solution Preparation Table
DMSO/Ethanol
1mg5mg10mg50mg
1 mM4.6256 mL23.1278 mL46.2556 mL231.2780 mL
5 mM0.9251 mL4.6256 mL9.2511 mL46.2556 mL
10 mM0.4626 mL2.3128 mL4.6256 mL23.1278 mL
20 mM0.2313 mL1.1564 mL2.3128 mL11.5639 mL
DMSO
1mg5mg10mg50mg
50 mM0.0925 mL0.4626 mL0.9251 mL4.6256 mL
100 mM0.0463 mL0.2313 mL0.4626 mL2.3128 mL

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