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Methoxsalen

Catalog No. T1548 CAS 298-81-7

Synonyms: 8-甲氧基补骨脂素, Xanthotoxin, 8-MOP, NCI-C55903, 8-Methoxypsoralen, 甲氧沙林

Methoxsalen is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.

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Methoxsalen, CAS 298-81-7

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Purity: 98%

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Description	Methoxsalen is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.
In vitro	Methoxsalen inhibits CYP2A6 (Ki = 0.8 μM) with about 3.5- 94-fold greater potency than other P450s, except for CYP1A2 (Ki = 0.2 μM). Methoxsalen shows noncompetitive inhibition of nicotine metabolism, with an apparent Ki value of 0.1 μM in cDNA-expressing microsomes. [1] Methoxsalen is metabolized in human liver microsomes at the rate of 50-100 pmol/mg protein/min (approx. 30% of the activity in mouse liver microsomes). Methoxsalen is a very potent inhibitor of human cytochrome P450 2A6 (CYP2A6) and mouse Cyp2a-5-mediated coumarin 7-hydroxylation in vitro. [2]
In vivo	Methoxsalen results in a significant decrease in the following factors: number and diameter of corpus lutei, Graafian follicles, diameter of granulosa cell layer and oocytes, number of primordial and primary and growing follicles, while the number of atretic follicle is increased. Methoxsalen also significantly reduces circulating estrogen levels in blood serum of oogenesis Balb/C mice. [3] Methoxsalen dose-dependently stimulates a sustained increase in short-circuit current in the mouse jejunum. Methoxsalen increases the open probability of the basolateral IK(Ca) channel of isolated crypts in the mouse jejunum. [4] Methoxsalen effectively reverses trimethyltin (TMT)-induced memory impairment on both Y-maze and passive avoidance tests in mice. Methoxsalen inhibits brain AchE activity. Methoxsalen significantly ameliorates the level of oxidative stress. [5]

Synonyms	8-甲氧基补骨脂素, Xanthotoxin, 8-MOP, NCI-C55903, 8-Methoxypsoralen, 甲氧沙林
Molecular Weight	216.19
Formula	C12H8O4
CAS No.	298-81-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <1 mg/mL

Ethanol: 5 mg/mL (23.12 mM)

DMSO: 40 mg/mL (185 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zhang W, et al. Drug Metab Dispos,2001, 29(6), 897-902. 2. Mäenpää J, et al. Biochem Pharmacol. 1994 Oct 7;48(7):1363-9. 3. Farhadi M, et al. Cell J,2014, 15(4), 348-355. 4. Hamilton KL, et al. Exp Physiol,2002, 87(4), 437-445. 5. Kim JK, et al. Biosci Biotechnol Biochem,2011, 75(10), 1984-1989.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library Traditional Chinese Medicine Monomer Library Anti-Obesity Compound Library Inhibitor Library Drug-induced Liver Injury (DILI) Compound Library Natural Product Library for HTS Anti-Tumor Natural Product Library DNA Damage & Repair Compound Library Immunology/Inflammation Compound Library

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Keywords

Methoxsalen 298-81-7 DNA损伤和修复代谢 DNA P450 CYPs Cytochrome P450 NCI-C55903 Xanthotoxin 8-MOP inhibit Inhibitor 8-Methoxypsoralen inhibitor

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