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ME1111

Catalog No. T16033 CAS 1391758-52-3

ME1111, a succinate dehydrogenase inhibitor of Trichophyton species, serves as an antifungal agent effective against dermatophytes. Notably proficient in penetrating human nails, it is utilized in onychomycosis research.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ME1111, CAS 1391758-52-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 118.00
5 mg	In stock	$ 291.00
10 mg	In stock	$ 432.00
25 mg	In stock	$ 715.00
50 mg	In stock	$ 987.00
100 mg	In stock	$ 1,360.00
500 mg	In stock	$ 2,730.00
1 mL * 10 mM (in DMSO)	In stock	$ 267.00

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Purity: 100%

Biological Description

Chemical Properties

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Description

In vitro

ME1111 (0.125, 0.0625 μg/mL; 4, 8, 12 h) inhibits T. mentagrophytes TIMM 2789 (MICs: 0.5 μg/mL and 0.25 μg/mL in RPMI 1640 medium and SDB, respectively).[2]
ME1111 strongly inhibits the succinate-2,6-dichlorophenolindophenol reductase reaction in Trichophyton rubrum and T. mentagrophytes (IC50: 0.029 μg/mL, 0.025 μg/mL) but only shows moderate inhibition of the same reaction in human cell lines.[2]

Molecular Weight	202.25
Formula	C12H14N2O
CAS No.	1391758-52-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (445.0 mM), Sonication is recommended.

References and Literature

1. Nishiyama Y, et al. Morphological Effect of the New Antifungal Agent ME1111 on Hyphal Growth of Trichophyton mentagrophytes, Determined by Scanning and Transmission Electron Microscopy. Antimicrob Agents Chemother. 2016 Dec 27;61(1). 2. Takahata S, et al. Mechanism of Action of ME1111, a Novel Antifungal Agent for Topical Treatment of Onychomycosis. Antimicrob Agents Chemother. 2015 Nov 23;60(2):873-80. 3. Tabata Y, et al. Characterization of Antifungal Activity and Nail Penetration of ME1111, a New Antifungal Agent for Topical Treatment of Onychomycosis. Antimicrob Agents Chemother. 2015;60(2):1035-1039.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Bioactive Compound Library Bioactive Compounds Library Max Clinical Compound Library

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Keywords

ME1111 1391758-52-3 Microbiology/Virology Others Antifungal ME-1111 ME 1111 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.