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Pneumocandin B0

Name: Pneumocandin B0
Brand: TargetMol
SKU: T5804
Price: 127 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5804Cas No. 135575-42-7

Alias L-688786

Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.

Pneumocandin B0

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Purity: 99.83%

Catalog No. T5804Alias L-688786Cas No. 135575-42-7

Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$38	In Stock	In Stock
50 mg	$58	-	In Stock
100 mg	$86	-	In Stock
200 mg	$127	-	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.83%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Pneumocandin B0 AI Summary

Pneumocandin B0 exhibits multifaceted bioactivities, including potent inhibitory activity against wild type Candida albicans 1,3-beta-D-glucan synthase with an IC50 of 35.7 nM, although another assay result indicates an IC50 value of 70.0 nM. It demonstrates strong antifungal properties against various Candida species, including strains with resistance mutations, with a minimum fungicidal concentration (MFC) of 0.25 mg/ml. Additionally, it exhibits antibacterial activity against Escherichia coli but is inactive against Staphylococcus aureus. The compound's antifungal efficacy is enhanced in the presence of human serum, as indicated by reduced minimum inhibitory concentrations (MIC) for several Candida strains. In a mouse model infected with Candida albicans, the compound shows a dose-dependent reduction in fungal burden, indicating its potential as an effective antifungal agent..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Pneumocandin B0 (L-688786) is a natural product and a key intermediate in the synthesis of the antifungal agent.
Synonyms	L-688786

Chemical Properties

Molecular Weight	1065.21
Formula	C₅₀H₈₀N₈O₁₇
Cas No.	135575-42-7
Smiles	[H][C@@]12C[C@@H](O)CN1C(=O)[C@@]([H])(NC(=O)[C@H](C[C@@H](O)[C@@H](O)NC(=O)[C@]1([H])[C@@H](O)CCN1C(=O)[C@@]([H])(NC(=O)[C@@]([H])(NC2=O)[C@H](O)[C@@H](O)c1ccc(O)cc1)[C@H](O)CC(N)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@@H](C)O
Relative Density.	1.41g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (93.88 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (3.76 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9388 mL	4.6939 mL	9.3878 mL	46.9391 mL
5 mM	0.1878 mL	0.9388 mL	1.8776 mL	9.3878 mL
10 mM	0.0939 mL	0.4694 mL	0.9388 mL	4.6939 mL
20 mM	0.0469 mL	0.2347 mL	0.4694 mL	2.3470 mL
50 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.9388 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc