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Hydroxytyrosol

Name: Hydroxytyrosol
Brand: TargetMol
SKU: T3412
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3412Cas No. 10597-60-1

Alias Dihydroxyphenylethanol, 3-Hydroxytyrosol, 3,4-dihydroxyphenylethanol, 2-(3,4-Di-hydroxyphenyl)-ethanol

Hydroxytyrosol (2-(3,4-Di-hydroxyphenyl)-ethanol) is an active ingredient extracted from the olive. It is one of the most efficient and secure antioxidants and can be used in the cardiovascular drugs.

Hydroxytyrosol

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Purity: 99.86%

Catalog No. T3412Alias Dihydroxyphenylethanol, 3-Hydroxytyrosol, 3,4-dihydroxyphenylethanol, 2-(3,4-Di-hydroxyphenyl)-ethanolCas No. 10597-60-1

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$45	In Stock	In Stock
25 mg	$67	In Stock	In Stock
50 mg	$89	In Stock	In Stock
100 mg	$144	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.86%

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Product Introduction

Hydroxytyrosol AI Summary

Hydroxytyrosol exhibits a broad spectrum of bioactivities, including significant antioxidant activity demonstrated by DPPH radical scavenging (IC50 of 3.71 µg/mL) and ABTS radical scavenging (3.4 mmol trolox equivalent). It shows cytotoxicity against human HeLa (IC50 of 70.0 µg/mL) and DG75 cells (IC50 of 58.0 µg/mL) after 48 hours by MTT assay. Antibacterial properties are observed against several strains, including Pseudomonas aeruginosa and Escherichia coli (MIC ranging from 62.5 to 125.0 µg/mL), while antifungal activity is demonstrated against Candida albicans and Aspergillus niger (MIC of 125.0 µg/mL and 250.0 µg/mL, respectively). The compound also exhibits antiviral activity against Influenza A virus (IC50 of 17,530 nM), with a selectivity index of >9.82. In terms of cell proliferation, it inhibits the growth of HT-29 cells in a dose-dependent manner and induces cell cycle arrest at multiple phases. The compound's hydrophobicity, indicated by a log Kow value of 0.809, suggests moderate to low bioavailability. It also inhibits several enzymes: alpha-glucosidase (IC50 of 109,300 nM), NADPH oxidase (IC50 of 7,500 nM), and 5-lipoxygenase (IC50 of 13,000 nM). Further bioactivities include inhibiting platelet aggregation and thromboxane synthesis, neuroprotective effects in a diabetic retinopathy model, hypoglycemic and antihyperlipidemic activities, and antioxidative effects, including increased SOD levels and reduced MDA levels in mice models. It shows antiproliferative activity against various cancer cell lines like PANC-1, PC-3, and SW480. Lastly, it is an inhibitor of BACE1 with a highly potent IC50 value of 35.0 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Hydroxytyrosol (2-(3,4-Di-hydroxyphenyl)-ethanol) is an active ingredient extracted from the olive. It is one of the most efficient and secure antioxidants and can be used in the cardiovascular drugs.
Synonyms	Dihydroxyphenylethanol, 3-Hydroxytyrosol, 3,4-dihydroxyphenylethanol, 2-(3,4-Di-hydroxyphenyl)-ethanol

Chemical Properties

Molecular Weight	154.16
Formula	C₈H₁₀O₃
Cas No.	10597-60-1
Smiles	OCCc1ccc(O)c(O)c1
Relative Density.	1.321 g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 260 mg/mL (1686.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (32.43 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.4868 mL	32.4338 mL	64.8677 mL	324.3383 mL
5 mM	1.2974 mL	6.4868 mL	12.9735 mL	64.8677 mL
10 mM	0.6487 mL	3.2434 mL	6.4868 mL	32.4338 mL
20 mM	0.3243 mL	1.6217 mL	3.2434 mL	16.2169 mL
50 mM	0.1297 mL	0.6487 mL	1.2974 mL	6.4868 mL
100 mM	0.0649 mL	0.3243 mL	0.6487 mL	3.2434 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc