Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 66.00 | |
10 mg | In stock | $ 91.00 | |
25 mg | In stock | $ 188.00 | |
50 mg | In stock | $ 281.00 | |
100 mg | In stock | $ 422.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 72.00 |
Description | Lofepramine (Leo 640) is a potent tricyclic antidepressant that is extensively metabolized to desipramine. It inhibits the serotonin and norepinephrine transporters by inhibiting neurons with Kd values of 70 and 5.4 nM, respectively, with weak antagonism of serotonin, histamine and muscarinic receptors. |
Targets&IC50 | serotonin:70 nM(Kd), norepinephrine transporter:5.4 nM(Kd) |
Synonyms | Gamanil, Amplit, Leo 640, Lopramine |
Molecular Weight | 418.96 |
Formula | C26H27ClN2O |
CAS No. | 23047-25-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (114.57 mM)
You can also refer to dose conversion for different animals. More
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Lofepramine 23047-25-8 GPCR/G Protein Neuroscience Norepinephrine 5-HT Receptor Inhibitor inhibit Gamanil Amplit Leo 640 Lopramine inhibitor