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Levobetaxolol hydrochloride

Catalog No. T6565 CAS 116209-55-3

Synonyms: Betaxon, (S)-Betaxolol hydrochloride, AL-1577A, Levobetaxolol HCl

Levobetaxolol hydrochloride ((S)-Betaxolol hydrochloride) is a beta-adrenergic receptor inhibitor (beta blocker), used to lower the pressure in the eye in treating conditions such as glaucoma.

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Levobetaxolol hydrochloride Chemical Structure

Levobetaxolol hydrochloride, CAS 116209-55-3

Pack Size	Availability	Price/USD
10 mg	In stock	$ 33.00
25 mg	In stock	$ 50.00
50 mg	In stock	$ 73.00
100 mg	In stock	$ 123.00
200 mg	In stock	$ 198.00
500 mg	In stock	$ 329.00
1 mL * 10 mM (in DMSO)	In stock	$ 39.00

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Purity: 99.69%

Purity: 99.57%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Levobetaxolol hydrochloride ((S)-Betaxolol hydrochloride) is a beta-adrenergic receptor inhibitor (beta blocker), used to lower the pressure in the eye in treating conditions such as glaucoma.
Targets&IC50	β2-adrenoceptor:32.6 nM(Ki), β1-adrenoceptor:0.76 nM(Ki)
In vitro	Levobetaxolol potently antagonizes functional activities at cloned human β1 and β2 receptors, and also at guinea pig atrial β1, tracheal β2 and rat colonic β3 receptors with IC50s of 33.2 nM, 2970 nM and 709 nM, respectively. Levobetaxolol (Ki = 16.4 nM) is more potent than dextrobetaxolol (Ki = 2.97 μM) at inhibiting isoproterenol-induced cAMP production in human non-pigmented ciliary epithelial cells. [1] Levobetaxolol (topically applied) has been shown to reach the back of the eye in sufficient quantities to protect retinal ganglion cells from various types of insults. Levobetaxolol displaces [3H]-nitrendipine for L-type voltage-dependent calcium channel receptor with IC50 of 29.5 μM in rat cortex. Levobetaxolol reduces NMDA-stimulated 45Ca2+ influx by 47.3%. Levobetaxolol (topically applied) reduces the b-wave amplitude caused by ischaemia/reperfusion. [2]
In vivo	Levobetaxolol (150 mg/eye) is more potent than dextrobetaxolol, reducing intraocular pressure by 25.9% in conscious ocular hypertensive cynomolgus monkeys. [1] Levobetaxolol (20 mg/kg) significant protects retinal function and results in significantly thicker the RPE and outer nuclear layer in a photic-induced retinopathy rat model. Levobetaxolol (20 mg/kg) results in a 10-fold up-regulation of bFGF and a two-fold up-regulation of CNTF mRNA levels, trophic factors that have been shown to inhibit retinal degeneration in a number of species. [3]

Synonyms	Betaxon, (S)-Betaxolol hydrochloride, AL-1577A, Levobetaxolol HCl
Molecular Weight	343.89
Formula	C18H29NO3·HCl
CAS No.	116209-55-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 64 mg/mL (186.1 mM)

Ethanol: 64 mg/mL (186.1 mM)

H2O: 63 mg/mL (183.2 mM)

References and Literature

1. Sharif NA, et al. J Ocul Pharmacol Ther, 2001, 17(4), 305-317. 2. Osborne NN, et al. Brain Res Bull, 2004, 62(6), 525-528. 3. Agarwal N, et al. Exp Eye Res, 2002, 74(4), 445-453.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Membrane Protein-targeted Compound Library Inhibitor Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Cancer Drug Library GPCR Compound Library Anti-Cardiovascular Disease Compound Library Anti-COVID-19 Compound Library

Related Products

Related compounds with same targets

Efloxate (S)-(-)-Propranolol hydrochloride OPC-28326 AL 34662 Carazolol Tetrahydrozoline hydrochloride N-methyltyramine ZK-90055 hydrochloride

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Keywords

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