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Endocrinology/Hormones Thyroid hormone receptor(THR) L-Thyroxine sodium salt pentahydrate

L-Thyroxine sodium salt pentahydrate

Catalog No. T15699   CAS 6106-07-6
Synonyms: Sodium levothyroxine pentahydrate, Levothyroxine

L-Thyroxine sodium salt pentahydrate is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

L-Thyroxine sodium salt pentahydrate, CAS 6106-07-6
Pack Size Availability Price/USD Quantity
5 mg Inquiry 50.00
500 mg Inquiry 68.00
1 g Inquiry 87.00
1 mL * 10 mM (in DMSO) Inquiry 74.00
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Purity 98.00%
Biological Description
Chemical Properties
Storage & Solubility Information
Description L-Thyroxine sodium salt pentahydrate is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).
Targets&IC50 Thyroid Hormone Receptor,  
In vitro
In vivo L-Thyroxine (T4) and Triiodothyronine (T3) hormones are known to modulate the expression of ionic channels, pumps, and regulatory contractile proteins. Moreover, thyroid hormones have been shown to influence calcium homeostasis and flux responsible for excitation and contractility, with L-Thyroxine and Triiodothyronine modulating its pharmacological control and secretion. Deiodinases, which catalyze the conversion of thyroxine (pro-hormone) to the active thyroid hormone, is associated with thyroid-stimulating hormone (TSH) levels. DIO1 and DIO2 catalyze the activation of thyroid hormone secretion in contrast to DIO3 playing role inactivation of the secretion. Activities of DIO1 and DIO2 play a pivotal role in the negative feedback regulation of pituitary TSH secretion [1]. A significant decrease in the levels of both Triiodothyronine and L-Thyroxine is observed when compared to the control group fed with a standard diet (p<0.001), in rats fed 12 weeks with the iodine-free diet. An increase in L-Thyroxine levels is observed (p=0.02) while Triiodothyronine levels remain virtually similar to the control group (p=0.19), in the group treated with low doses of L-Thyroxine. Rats treated with high doses of L-Thyroxine show a significant increase in both Triiodothyronine and L-Thyroxine circulating concentrations compared to the non-treated hypothyroid group (p<0.001 and p=0.004, respectively) and a significant increase in L-Thyroxine levels when compared to the control values (p=0.03) [2].
Synonyms Sodium levothyroxine pentahydrate , Levothyroxine
Purity 98.00%
Molecular Weight 888.93
Formula C15H20I4NNaO9
CAS No. 6106-07-6

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 28 mg/mL (31.50 mM)

H2O: < 0.1 mg/mL (insoluble)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Jan 11. 2. Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 9;2(4):144-149.

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